RECQL5

Gene Symbol	RECQL5
Entrez Gene	9400
Alt Symbol	RECQ5
Species	Human
Gene Type	protein-coding
Description	RecQ protein-like 5
Other Description	ATP-dependent DNA helicase Q5\|DNA helicase, RecQ-like type 5
Swissprots	Q9UNC8 Q9P1W7 Q9H0B1 Q6P4G0 O94762
Accessions	AAD43061 AAD43062 EAW89289 EAW89290 EAW89291 EAW89292 EAW89293 EAW89294 EAW89295 O94762 AB006533 BAA74454 AB042823 BAA95952 AB042824 BAA95953 AB042825 BAA95954 AF193041 AAG22469 AI537883 AI684041 AK075084 BAG52064 AK304168 BAH14123 AL136869 CAB66803 BC000570 AAH00570 BC005103 AAH05103 BC016911 AAH16911 BC042989 BC063440 AAH63440 BI116483 BP272369 CR533497 CAG38528 DB091647 EF491799 EF560729 ABQ59039 N53539 XM_005257818 XP_005257875 XM_005257822 XP_005257879 XM_005257823 XP_005257880 XM_006722186 XP_006722249 XM_011525482 XP_011523784 XM_011525483 XP_011523785 XM_011525484 XP_011523786 XM_011525485 XP_011523787 XM_011525486 XP_011523788 NM_001003715 NP_001003715 NM_001003716 NP_001003716 NM_004259 NP_004250
Function	Isoform beta is a DNA helicase that plays an important role in DNA replication, transcription and repair. Inhibits elongation of stalled transcripts at DNA damage sites by binding to the RNA polymerase II subunit POLR2A and blocking the TCEA1 binding site. Required for mitotic chromosome separation after cross-over events and cell cycle progress. Required for efficient DNA repair, including repair of inter-strand cross-links. Stimulates DNA decatenation mediated by TOP2A. Prevents sister chromatid exchange and homologous recombination. {ECO:0000269\|PubMed:20231364, ECO:0000269\|PubMed:20348101, ECO:0000269\|PubMed:20643585, ECO:0000269\|PubMed:22013166, ECO:0000269\|PubMed:22973052, ECO:0000269\|PubMed:23715498, ECO:0000269\|PubMed:23748380}.
Subcellular Location	Isoform Gamma: Cytoplasm.
Tissue Specificity	Ubiquitous.

RecQL5 (1A2) Mouse mAb - 5847 from Cell Signaling Technology

Prices	$246.00
Sizes	100 µl (10 western blots)
Host	Mouse
Clonality	Monoclonal
Clone	1A2

Western blot analysis of extracts from Daudi and 293 cells using RecQL5 (1A2) Mouse mAb.

RecQL5 (H-98) - sc-366670 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Rabbit
Clonality	Polyclonal

RecQL5 (N-20) - sc-16157 from Santa Cruz Biotechnology

Prices	$279.00
Sizes	200 µg/ml
Host	Goat
Clonality	Polyclonal

Anti-RECQL5 antibody - ab91422 from Abcam

Prices	$370.00
Sizes	100 µg
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) analysis of human breast carcinoma tissue labelling RECQL5 with ab91422 at 1/1000 (1µg/ml). Detection: DAB.

Anti-RECQL5 antibody - ab168620 from Abcam

Prices	$370.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

All lanes : Anti-RECQL5 antibody (ab168620) at 1 µg/mlLane 1 : RECQL5 transfected 293T cell lysateLane 2 : Non-transfected 293T cell lysateLysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-RECQL5 antibody - ab123501 from Abcam

Prices	$428.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

ab123501 at 1/250 dilution staining RECQL5 in Human breast carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

Anti-RECQL5 antibody - C-terminal - ab176443 from Abcam

Host	Rabbit
Clonality	Polyclonal

Anti-RECQL5 antibody - C-terminal (ab176443) at 1/1000 dilution + HeLa whole cell extract

Anti-RECQ5 / RECQL5 Antibody (aa662-691, AP) - LS-C239907 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa662-691, APC) - LS-C239908 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa662-691, PE) - LS-C239912 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa662-691, FITC) - LS-C239910 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa662-691, Biotin) - LS-C239909 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa662-691, Azide-free, HRP) - LS-C248645 from LifeSpan Bioscience

Prices	$545.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa450-500) - LS-C289254 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa662-691) - LS-C324604 from LifeSpan Bioscience

Prices	$345.00
Sizes	200 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa650-700) - LS-C289256 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Anti-RECQ5 / RECQL5 Antibody (aa431-480) - LS-C40302 from LifeSpan Bioscience

Prices	$365.00
Sizes	50 µg
Host	Rabbit
Clonality	Polyclonal

RECQL5 antibody LS-C40302 Western blot of Transfected 293T cell lysate.

Anti-RECQ5 / RECQL5 Antibody (aa662-691) - LS-C155969 from LifeSpan Bioscience

Prices	$295.00
Sizes	400 µl
Host	Rabbit
Clonality	Polyclonal

RECQL5 Antibody western blot of human Uterus tissue lysates (35 ug/lane). The RECQL5 antibody detected the RECQL5 protein (arrow).

Anti-RECQ5 / RECQL5 Antibody (aa1-50) - LS-C289252 from LifeSpan Bioscience

Prices	$375.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Detection of Human RECQ5 by Immunohistochemistry. Sample: FFPE section of human breast carcinoma. Antibody: Affinity purified rabbit anti-RECQ5 used at a dilution of 1:1000 (1 ug/ml). Detection: DAB.

Anti-RECQ5 / RECQL5 Antibody (aa1-50) - LS-C286897 from LifeSpan Bioscience

Prices	$415.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

RECQL5 Antibody - NBP1-83438 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: RECQL5 Antibody [NBP1-83438] - Analysis in human cell line A-549.

RECQL5 Antibody - NBP1-83437 from Novus Biologicals

Prices	$419.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Immunohistochemistry-Paraffin: RECQL5 Antibody [NBP1-83437] - Staining of human kidney shows strong membranous positivity in cells of tubules.

RECQL5 Antibody - H00009400-B01P from Novus Biologicals

Prices	$359.00
Sizes	50 µg
Host	Mouse
Clonality	Polyclonal

Western Blot: RECQL5 Antibody [H00009400-B01P] - Analysis of RECQL5 expression in transfected 293T cell line by RECQL5 polyclonal antibody. Lane 1: RECQL5 transfected lysate(47.85 KDa). Lane 2: Non-transfected lysate.

RECQL5 Antibody - NBP1-40340 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: RECQL5 Antibody [NBP1-40340] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-RECQ5 antibody used for WB at 0.1 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 10 mcg/mg lysate. RECQ5 was also immunoprecipitated by rabbit anti-RECQ5 antibodies NBP1-40339 and NBP1-40341 which recognize other epitopes.

RECQL5 Antibody - NBP1-40341 from Novus Biologicals

Prices	$359.00
Sizes	100 µl
Host	Rabbit
Clonality	Polyclonal

Western Blot: RECQL5 Antibody [NBP1-40341] - Whole cell lysate (5, 15 and 50 mcg for WB; 1 mg for IP, 20% of IP loaded) from HeLa cells. Antibodies: Affinity purified rabbit anti-RECQ5 antibody used for WB at 0.04 mcg/ml (A) and 1 mcg/ml (B) and used for IP at 10 mcg/mg lysate. RECQ5 was also immunoprecipitated by rabbit anti-RECQ5 antibodies NBP1-40339 and NBP1-40340which recognize upstream epitopes.

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