| Gene Symbol |
LRRC26
|
| Entrez Gene |
389816
|
| Alt Symbol |
CAPC, bA350O14.10
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
leucine rich repeat containing 26
|
| Other Description |
BK channel auxiliary gamma subunit LRRC26|BK channel auxilliary gamma subunit LRRC26|cytokeratin associated protein|cytokeratin-associated protein in cancer|leucine-rich repeat-containing protein 26
|
| Swissprots |
Q5VSG2 B9EIR7 C3RUL3 Q2I0M4
|
| Accessions |
Q2I0M4 BC140911 AAI40912 CB160046 DN996987 DQ355157 ABC79623 EU588721 ACO90295 NM_001013653 NP_001013675
|
| Function |
Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. {ECO:0000269|PubMed:20613726, ECO:0000269|PubMed:22547800}.
|
| Subcellular Location |
Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269|PubMed:15164053}.
|
| Tissue Specificity |
Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines. {ECO:0000269|PubMed:16585525, ECO:0000269|PubMed:19250639}.
|