Gene Symbol | LRRC26 |
---|---|
Entrez Gene | 389816 |
Alt Symbol | CAPC, bA350O14.10 |
Species | Human |
Gene Type | protein-coding |
Description | leucine rich repeat containing 26 |
Other Description | BK channel auxiliary gamma subunit LRRC26|BK channel auxilliary gamma subunit LRRC26|cytokeratin associated protein|cytokeratin-associated protein in cancer|leucine-rich repeat-containing protein 26 |
Swissprots | Q5VSG2 B9EIR7 C3RUL3 Q2I0M4 |
Accessions | Q2I0M4 BC140911 AAI40912 CB160046 DN996987 DQ355157 ABC79623 EU588721 ACO90295 NM_001013653 NP_001013675 |
Function | Auxiliary protein of the large-conductance, voltage and calcium-activated potassium channel (BK alpha). Required for the conversion of BK alpha channels from a high-voltage to a low- voltage activated channel type in non-excitable cells. These are characterized by negative membrane voltages and constant low levels of calcium. {ECO:0000269|PubMed:20613726, ECO:0000269|PubMed:22547800}. |
Subcellular Location | Cell membrane; Single-pass type I membrane protein. Cytoplasm, cytoskeleton. Note=Localizes to the cytoplasm when expressed at high levels. {ECO:0000269|PubMed:15164053}. |
Tissue Specificity | Isoform 1 is expressed highly in normal prostate and salivary gland, very weakly in colon, pancreas, and intestine, and not at all in other tissues. Isoform 1 is expressed highly in many cancer cell lines and in breast cancer, pancreatic cancer and colon cancer. Isoform 2 is expressed in cancer cell lines. {ECO:0000269|PubMed:16585525, ECO:0000269|PubMed:19250639}. |
LRRC26 CRISPR/Cas9 KO Plasmid (h) - sc-409111 from Santa Cruz Biotechnology
|
||||||||
LRRC26 HDR Plasmid (h) - sc-409111-HDR from Santa Cruz Biotechnology
|
||||||||
LRRC26 Double Nickase Plasmid (h) - sc-409111-NIC from Santa Cruz Biotechnology
|
||||||||
LRRC26 Double Nickase Plasmid (h2) - sc-409111-NIC-2 from Santa Cruz Biotechnology
|
||||||||
LRRC26 CRISPR Activation Plasmid (h) - sc-409111-ACT from Santa Cruz Biotechnology
|
||||||||
LRRC26 CRISPR Activation Plasmid (h2) - sc-409111-ACT-2 from Santa Cruz Biotechnology
|
||||||||
LRRC26 Lentiviral Activation Particles (h) - sc-409111-LAC from Santa Cruz Biotechnology
|
||||||||
LRRC26 Lentiviral Activation Particles (h2) - sc-409111-LAC-2 from Santa Cruz Biotechnology
|
||||||||
LRRC26 siRNA (h) - sc-92516 from Santa Cruz Biotechnology
|
||||||||
LRRC26 shRNA Plasmid (h) - sc-92516-SH from Santa Cruz Biotechnology
|
||||||||
LRRC26 shRNA (h) Lentiviral Particles - sc-92516-V from Santa Cruz Biotechnology
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN12718 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12718 from Sigma-Aldrich
|
||||||||
LRRC26 siRNA (Human) - CRJ7909 from Cohesion Biosciences
|
||||||||
Human LRRC26 siRNA - orb278410 from Biorbyt
|
||||||||
LRRC26 shRNA Plasmid (Human) - CHJ7909 from Cohesion Biosciences
|
||||||||
LRRC26 miRNA 3'UTR clone - MiUTR1H-08937 from Creative biogene
|