| Gene Symbol |
BAZ1B
|
| Entrez Gene |
9031
|
| Alt Symbol |
WBSCR10, WBSCR9, WSTF
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
bromodomain adjacent to zinc finger domain, 1B
|
| Other Description |
hWALp2|transcription factor WSTF|tyrosine-protein kinase BAZ1B|williams syndrome transcription factor|williams-Beuren syndrome chromosomal region 10 protein|williams-Beuren syndrome chromosomal region 9 protein
|
| Swissprots |
Q86UJ6 Q6P1K4 O95039 B9EGK3 O95277 O95247 D3DXE9 Q9UIG0
|
| Accessions |
AAD04720 AAP22332 EAW69679 EAW69680 EAW69681 Q9UIG0 AB032253 BAA89210 AF072810 AAC97879 AF084479 AAD08675 AK123274 BC041561 BC050599 BC065029 AAH65029 BC080544 BC136520 AAI36521 BU632531 DA739467 XM_005250683 XP_005250740 NM_032408 NP_115784 NM_023005
|
| Function |
Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMe
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136}. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
|
| Tissue Specificity |
Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.
|