BAZ1B
| Gene Symbol | BAZ1B |
|---|---|
| Entrez Gene | 9031 |
| Alt Symbol | WBSCR10, WBSCR9, WSTF |
| Species | Human |
| Gene Type | protein-coding |
| Description | bromodomain adjacent to zinc finger domain, 1B |
| Other Description | hWALp2|transcription factor WSTF|tyrosine-protein kinase BAZ1B|williams syndrome transcription factor|williams-Beuren syndrome chromosomal region 10 protein|williams-Beuren syndrome chromosomal region 9 protein |
| Swissprots | Q86UJ6 Q6P1K4 O95039 B9EGK3 O95277 O95247 D3DXE9 Q9UIG0 |
| Accessions | AAD04720 AAP22332 EAW69679 EAW69680 EAW69681 Q9UIG0 AB032253 BAA89210 AF072810 AAC97879 AF084479 AAD08675 AK123274 BC041561 BC050599 BC065029 AAH65029 BC080544 BC136520 AAI36521 BU632531 DA739467 XM_005250683 XP_005250740 NM_032408 NP_115784 NM_023005 |
| Function | Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMe |
| Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136}. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA. |
| Tissue Specificity | Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary. |
WSTF CRISPR/Cas9 KO Plasmid (h) - sc-404237 from Santa Cruz Biotechnology
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WSTF HDR Plasmid (h) - sc-404237-HDR from Santa Cruz Biotechnology
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WSTF Double Nickase Plasmid (h) - sc-404237-NIC from Santa Cruz Biotechnology
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WSTF Double Nickase Plasmid (h2) - sc-404237-NIC-2 from Santa Cruz Biotechnology
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WSTF CRISPR Activation Plasmid (h) - sc-404237-ACT from Santa Cruz Biotechnology
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WSTF CRISPR Activation Plasmid (h2) - sc-404237-ACT-2 from Santa Cruz Biotechnology
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WSTF Lentiviral Activation Particles (h) - sc-404237-LAC from Santa Cruz Biotechnology
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WSTF Lentiviral Activation Particles (h2) - sc-404237-LAC-2 from Santa Cruz Biotechnology
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WSTF siRNA (h) - sc-38619 from Santa Cruz Biotechnology
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WSTF shRNA Plasmid (h) - sc-38619-SH from Santa Cruz Biotechnology
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WSTF shRNA (h) Lentiviral Particles - sc-38619-V from Santa Cruz Biotechnology
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WSTF RNAi - H00009031-R02 from Novus Biologicals
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WSTF RNAi - H00009031-R01 from Novus Biologicals
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MISSION® esiRNA - EHU138161 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN3873 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3873 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08567 from Sigma-Aldrich
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BAZ1B siRNA (Human) - CRH5956 from Cohesion Biosciences
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BAZ1B - MBS8229465 from MyBioSource
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shRNA set against Human BAZ1B (NM_032408.3) - SHH245034 from Creative biogene
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Human BAZ1B siRNA - orb266458 from Biorbyt
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BAZ1B shRNA Plasmid (Human) - CHH5956 from Cohesion Biosciences
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BAZ1B miRNA 3'UTR clone - MiUTR3H-07881 from Creative biogene
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