BAZ1B

Gene Symbol	BAZ1B
Entrez Gene	9031
Alt Symbol	WBSCR10, WBSCR9, WSTF
Species	Human
Gene Type	protein-coding
Description	bromodomain adjacent to zinc finger domain, 1B
Other Description	hWALp2|transcription factor WSTF|tyrosine-protein kinase BAZ1B|williams syndrome transcription factor|williams-Beuren syndrome chromosomal region 10 protein|williams-Beuren syndrome chromosomal region 9 protein
Swissprots	Q86UJ6 Q6P1K4 O95039 B9EGK3 O95277 O95247 D3DXE9 Q9UIG0
Accessions	AAD04720 AAP22332 EAW69679 EAW69680 EAW69681 Q9UIG0 AB032253 BAA89210 AF072810 AAC97879 AF084479 AAD08675 AK123274 BC041561 BC050599 BC065029 AAH65029 BC080544 BC136520 AAI36521 BU632531 DA739467 XM_005250683 XP_005250740 NM_032408 NP_115784 NM_023005
Function	Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication. {ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136, ECO:0000269|PubMe
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00063, ECO:0000255|PROSITE-ProRule:PRU00475, ECO:0000269|PubMed:11980720, ECO:0000269|PubMed:15543136}. Note=Accumulates in pericentromeric heterochromatin during replication. Targeted to replication foci throughout S phase via its association with PCNA.
Tissue Specificity	Ubiquitously expressed with high levels of expression in heart, brain, placenta, skeletal muscle and ovary.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human WSTF protein fragment - ab152941 from Abcam Category Protein Source Wheat germ Species Human

Human WSTF protein fragment - ab196102 from Abcam Category Protein Source E. coli Species Human

Human WSTF protein fragment - ab196113 from Abcam Category Protein Source E. coli Species Human

BAZ1B / WSTF Antibody Blocking Peptide - LS-E14320 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

BAZ1B / WSTF Antibody Blocking Peptide - LS-E6552 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human WSTF Protein - H00009031-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

BAZ1B-Antibody-N-term-Blocking-Peptide - BP19326a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

BAZ1B / WSTF - H00009031-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

BAZ1B / WSTF - H00009031-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

BAZ1B fusion protein - Ag24403 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PET28a Species Human

Recombinant BAZ1B (1340-1457) protein - 31444 from ActiveMotif Category Protein Prices $395.00, $2,600.00 Sizes 100 μg, 1 mg Source E. coli Species Human

Recombinant Human BAZ1B, His&FLAG-tagged - BAZ1B-32H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human Tyrosine-protein kinase BAZ1B(BAZ1B) ,partial - CSB-YP883429HU CSB-EP883429HU CSB-BP883429HU CSB-MP883429HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Recombinant Human BAZ1B protein, GST-tagged - BAZ1B-57H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human BAZ1B protein, His-tagged - BAZ1B-58H from Creative Biomart Category Protein Source E.coli Species Human

BAZ1B Peptide, Human - M34GP01334H from Creative Peptides Category Peptide Source Synthetic. Species Human

WSTF Recombinant Protein Antigen - NBP2-57741PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Recombinant Human BAZ1B Protein, GST-tagged - BAZ1B-097H from Creative Biomart Category Protein Source Wheat Germ Species Human

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