Gene Symbol | TIPRL |
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Entrez Gene | 261726 |
Alt Symbol | TIP, TIP41 |
Species | Human |
Gene Type | protein-coding |
Description | TOR signaling pathway regulator |
Other Description | TIP41, TOR signaling pathway regulator-like|TIP41-like protein|putative MAPK-activating protein PM10|type 2A-interacting protein |
Swissprots | Q5HYB2 O75663 B2R8V3 Q8IZ86 |
Accessions | EAW90820 EAW90821 O75663 AB097034 BAC77387 AI167356 AK313520 BAG36300 AL049670 CAB41244 BC009506 AAH09506 BX431957 BX648646 CAI46265 XM_011509405 XP_011507707 NM_001031800 NP_001026970 NM_152902 NP_690866 |
Function | May be a allosteric regulator of serine/threonine- protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair. {ECO:0000269|PubMed:17384681}. |
Subcellular Location | Cytoplasm {ECO:0000269|PubMed:17944932}. |
Tip41 CRISPR/Cas9 KO Plasmid (h) - sc-416504 from Santa Cruz Biotechnology
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Tip41 HDR Plasmid (h) - sc-416504-HDR from Santa Cruz Biotechnology
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Tip41 Double Nickase Plasmid (h) - sc-416504-NIC from Santa Cruz Biotechnology
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Tip41 Double Nickase Plasmid (h2) - sc-416504-NIC-2 from Santa Cruz Biotechnology
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Tip41 CRISPR Activation Plasmid (h) - sc-416504-ACT from Santa Cruz Biotechnology
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Tip41 CRISPR Activation Plasmid (h2) - sc-416504-ACT-2 from Santa Cruz Biotechnology
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Tip41 Lentiviral Activation Particles (h) - sc-416504-LAC from Santa Cruz Biotechnology
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Tip41 Lentiviral Activation Particles (h2) - sc-416504-LAC-2 from Santa Cruz Biotechnology
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Tip41 siRNA (h) - sc-78723 from Santa Cruz Biotechnology
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Tip41 shRNA Plasmid (h) - sc-78723-SH from Santa Cruz Biotechnology
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Tip41 shRNA (h) Lentiviral Particles - sc-78723-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU056841 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21376 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21376 from Sigma-Aldrich
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TIPRL siRNA (Human) - CRJ6826 from Cohesion Biosciences
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TIPRL - MBS8217277 from MyBioSource
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Human TIPRL siRNA - orb277327 from Biorbyt
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TIPRL shRNA Plasmid (Human) - CHJ6826 from Cohesion Biosciences
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