SLC22A6

Gene Symbol SLC22A6
Entrez Gene 9356
Alt Symbol HOAT1, OAT1, PAHT, ROAT1
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic anion transporter), member 6
Other Description PAH transporter|hPAHT|hROAT1|organic anion transporter 1|para-aminohippurate transporter|renal organic anion transporter 1|solute carrier family 22 member 6
Swissprots Q9UEQ8 Q9UBG6 Q7LDA0 Q9NQC2 B2D0R6 Q4U2R8 A8MY93 Q8N192 O95742 O95187 Q9NQA6
Accessions ACB21049 CAB77184 EAW74129 EAW74130 EAW74131 EAW74132 Q4U2R8 AB009697 BAA75072 AB009698 BAA75073 AF057039 AAC70004 AF097490 AAD19356 AF104038 AAD10052 AF124373 AAD55356 AI017670 AJ251529 CAB94830 AJ271205 CAB97249 AK055764 BAG51569 AK091879 BAG52435 AK298374 BAG60612 BC033682 AAH33682 DA628191 DA629600 DB320467 DQ892080 ABM83006 DQ895273 ABM86199 NM_004790 NP_004781 NM_153276 NP_695008 NM_153277 NP_695009 NM_153278 NP_695010 NM_153279
Function Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarit
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269|PubMed:10049739, ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.

OAT1 (N-13) - sc-161978 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
OAT1 (N-13): sc-161978. Western blot analysis of OAT1 expression in mouse brain tissue extract.

Anti-SLC22A6 antibody - ab118346 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-SLC22A6 antibody (ab118346) at 5 µg/ml + Immunizing peptide at 0.2 µg

Anti-SLC22A6 antibody - ab131087 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin embedded Rat kidney tissue labelling SLC22A6 with ab131087 at 0.5 µg/ml.

Anti-SLC22A6 antibody - C-terminal - ab183086 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human breast cancer tissue labeling SLC22A6 using ab183086 at a 1/50 dilution, imageon the right is treated with the synthetic peptide.

Anti-SLC22A6 / OAT1 Antibody (C-Terminus) IHC-plus™ - LS-B8083 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SLC22A6 / NKT antibody IHC of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8083 dilution 5-10 ug/ml.

Anti-SLC22A6 / OAT1 Antibody (aa513-541) IHC-plus™ - LS-B10034 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-SLC22A6 / OAT1 antibody IHC staining of human kidney. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B10034 dilution 1:50.

Anti-SLC22A6 / OAT1 Antibody (C-Terminus) - LS-C17006 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (C-Terminus) - LS-C17007 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549, APC) - LS-C224088 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549, AP) - LS-C224089 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549, Biotin) - LS-C224090 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549, FITC) - LS-C224091 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549, Azide-free, HRP) - LS-C224092 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549, PE) - LS-C224093 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (N-Terminus) - LS-C80434 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Placenta lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-SLC22A6 / OAT1 Antibody (aa255-304) - LS-C291714 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (aa520-549) - LS-C330145 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-SLC22A6 / OAT1 Antibody (clone 1F2) - LS-C133997 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F2
Detection limit for recombinant GST tagged SLC22A6 is 3 ng/ml as a capture antibody.

Anti-SLC22A6 / OAT1 Antibody - LS-C192950 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of extracts of CEM cell lines, using SLC22A6 antibody.

Anti-SLC22A6 / OAT1 Antibody - LS-C331706 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of CEM cell lines, using SLC22A6 antibody.

Anti-SLC22A6 / OAT1 Antibody - LS-C332406 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry of paraffin-embedded human breast cancer tissue using SLC22A6 antibody.

Anti-SLC22A6 / OAT1 Antibody (aa534-550) - LS-C312836 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
SLC22A6 / OAT1 antibody. IHC(P): Rat Kidney Tissue.

SLC22A6 Antibody (1F2) - H00009356-M05 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 1F2

SLC22A6 Antibody - NBP1-69695 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC22A6 Antibody [NBP1-69695] - This Anti-SLC22A6 antibody was used in Western Blot of Fetal Lung tissue lysate at a concentration of 1ug/ml.

SLC22A6 Antibody - NBP1-69694 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: SLC22A6 Antibody [NBP1-69694] - This Anti-SLC22A6 antibody was used in Western Blot of Placenta tissue lysate at a concentration of 1ug/ml.
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