SLC22A6

Gene Symbol SLC22A6
Entrez Gene 9356
Alt Symbol HOAT1, OAT1, PAHT, ROAT1
Species Human
Gene Type protein-coding
Description solute carrier family 22 (organic anion transporter), member 6
Other Description PAH transporter|hPAHT|hROAT1|organic anion transporter 1|para-aminohippurate transporter|renal organic anion transporter 1|solute carrier family 22 member 6
Swissprots Q9UEQ8 Q9UBG6 Q7LDA0 Q9NQC2 B2D0R6 Q4U2R8 A8MY93 Q8N192 O95742 O95187 Q9NQA6
Accessions ACB21049 CAB77184 EAW74129 EAW74130 EAW74131 EAW74132 Q4U2R8 AB009697 BAA75072 AB009698 BAA75073 AF057039 AAC70004 AF097490 AAD19356 AF104038 AAD10052 AF124373 AAD55356 AI017670 AJ251529 CAB94830 AJ271205 CAB97249 AK055764 BAG51569 AK091879 BAG52435 AK298374 BAG60612 BC033682 AAH33682 DA628191 DA629600 DB320467 DQ892080 ABM83006 DQ895273 ABM86199 NM_004790 NP_004781 NM_153276 NP_695008 NM_153277 NP_695009 NM_153278 NP_695010 NM_153279
Function Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarit
Subcellular Location Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269|PubMed:10049739, ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.

OAT1 CRISPR/Cas9 KO Plasmid (h) - sc-404284 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 HDR Plasmid (h) - sc-404284-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 Double Nickase Plasmid (h) - sc-404284-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 Double Nickase Plasmid (h2) - sc-404284-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 CRISPR Activation Plasmid (h) - sc-404284-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 CRISPR Activation Plasmid (h2) - sc-404284-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 Lentiviral Activation Particles (h) - sc-404284-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 Lentiviral Activation Particles (h2) - sc-404284-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

OAT1 siRNA (h) - sc-96343 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OAT1 shRNA Plasmid (h) - sc-96343-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

OAT1 shRNA (h) Lentiviral Particles - sc-96343-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

SLC22A6 RNAi - H00009356-R05 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SLC22A6 RNAi - H00009356-R03 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SLC22A6 RNAi - H00009356-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

SLC22A6 RNAi - H00009356-R02 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU044331 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN19470 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND19470 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR00798 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr00798

SLC22A6 siRNA (Human) - CRH6194 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

SLC22A6 RNAi - H00009356-R04 from Novus Biologicals

Category siRNA
Prices $409.00
Sizes 20 nmol
Species Reactivities Human

SLC22A6 - MBS827397 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human SLC22A6 (NM_004790.4) - SHH409228 from Creative biogene

Category siRNA
Species Reactivities Human

SLC22A6 shRNA Plasmid (Human) - CHH6194 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

SLC22A6 miRNA 3'UTR clone - MiUTR4H-TG08183 from Creative biogene

Species Reactivities Human
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