| Gene Symbol |
SLC22A6
|
| Entrez Gene |
9356
|
| Alt Symbol |
HOAT1, OAT1, PAHT, ROAT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
solute carrier family 22 (organic anion transporter), member 6
|
| Other Description |
PAH transporter|hPAHT|hROAT1|organic anion transporter 1|para-aminohippurate transporter|renal organic anion transporter 1|solute carrier family 22 member 6
|
| Swissprots |
Q9UEQ8 Q9UBG6 Q7LDA0 Q9NQC2 B2D0R6 Q4U2R8 A8MY93 Q8N192 O95742 O95187 Q9NQA6
|
| Accessions |
ACB21049 CAB77184 EAW74129 EAW74130 EAW74131 EAW74132 Q4U2R8 AB009697 BAA75072 AB009698 BAA75073 AF057039 AAC70004 AF097490 AAD19356 AF104038 AAD10052 AF124373 AAD55356 AI017670 AJ251529 CAB94830 AJ271205 CAB97249 AK055764 BAG51569 AK091879 BAG52435 AK298374 BAG60612 BC033682 AAH33682 DA628191 DA629600 DB320467 DQ892080 ABM83006 DQ895273 ABM86199 NM_004790 NP_004781 NM_153276 NP_695008 NM_153277 NP_695009 NM_153278 NP_695010 NM_153279
|
| Function |
Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarit
|
| Subcellular Location |
Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269|PubMed:10049739, ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.
|