SLC22A6

Gene Symbol	SLC22A6
Entrez Gene	9356
Alt Symbol	HOAT1, OAT1, PAHT, ROAT1
Species	Human
Gene Type	protein-coding
Description	solute carrier family 22 (organic anion transporter), member 6
Other Description	PAH transporter|hPAHT|hROAT1|organic anion transporter 1|para-aminohippurate transporter|renal organic anion transporter 1|solute carrier family 22 member 6
Swissprots	Q9UEQ8 Q9UBG6 Q7LDA0 Q9NQC2 B2D0R6 Q4U2R8 A8MY93 Q8N192 O95742 O95187 Q9NQA6
Accessions	ACB21049 CAB77184 EAW74129 EAW74130 EAW74131 EAW74132 Q4U2R8 AB009697 BAA75072 AB009698 BAA75073 AF057039 AAC70004 AF097490 AAD19356 AF104038 AAD10052 AF124373 AAD55356 AI017670 AJ251529 CAB94830 AJ271205 CAB97249 AK055764 BAG51569 AK091879 BAG52435 AK298374 BAG60612 BC033682 AAH33682 DA628191 DA629600 DB320467 DQ892080 ABM83006 DQ895273 ABM86199 NM_004790 NP_004781 NM_153276 NP_695008 NM_153277 NP_695009 NM_153278 NP_695010 NM_153279
Function	Involved in the renal elimination of endogenous and exogenous organic anions. Functions as organic anion exchanger when the uptake of one molecule of organic anion is coupled with an efflux of one molecule of endogenous dicarboxylic acid (glutarate, ketoglutarate, etc). Mediates the sodium-independent uptake of 2,3-dimercapto-1-propanesulfonic acid (DMPS) (By similarity). Mediates the sodium-independent uptake of p- aminohippurate (PAH), ochratoxin (OTA), acyclovir (ACV), 3'-azido- 3-'deoxythymidine (AZT), cimetidine (CMD), 2,4-dichloro- phenoxyacetate (2,4-D), hippurate (HA), indoleacetate (IA), indoxyl sulfate (IS) and 3-carboxy-4-methyl-5-propyl-2- furanpropionate (CMPF), cidofovir, adefovir, 9-(2- phosphonylmethoxyethyl) guanine (PMEG), 9-(2- phosphonylmethoxyethyl) diaminopurine (PMEDAP) and edaravone sulfate. PAH uptake is inhibited by p- chloromercuribenzenesulphonate (PCMBS), diethyl pyrocarbonate (DEPC), sulindac, diclofenac, carprofen, glutarate and okadaic acid (By similarit
Subcellular Location	Cell membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Tissue Specificity	Strongly expressed in kidney and to a lower extent in liver, skeletal muscle, brain and placenta. Found at the basolateral membrane of the proximal tubule. {ECO:0000269|PubMed:10049739, ECO:0000269|PubMed:10462545, ECO:0000269|PubMed:10964714, ECO:0000269|PubMed:9887087, ECO:0000269|PubMed:9950961}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SLC22A6 protein fragment - ab152973 from Abcam Category Protein Source Wheat germ Species Human

SLC22A6 Antibody Blocking Peptide - LS-E10019 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

SLC22A6 Antibody Blocking Peptide - LS-E15293 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human SLC22A6 Protein - H00009356-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

SLC22A6-Antibody-C-Term-Blocking-Peptide - BP9237b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SLC22A6 Protein Lysate (APL10520) - APL10520 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SLC22A6 Protein Lysate (APL10521) - APL10521 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SLC22A6 Protein Lysate (APL10522) - APL10522 from Aviva Systems Biology Category Protein Prices $219.00 Sizes 200 µg

SLC22A6 Blocking Peptide - 33R-2764 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

SLC22A6 Blocking Peptide - 33R-1168 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PAHT Blocking Peptide - abx063579 from Abbexa Category Peptide Species Human, Monkey

SLC22A6 / OAT1 - H00009356-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SLC22A6 / OAT1 - H00009356-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SLC22A6 fusion protein - Ag24234 from Proteintech Group Category Protein Prices $199.00 Sizes 50 Source E. coli -derived, PGEX-4T Species Human

SLC22A6 fusion protein - ag5072 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

OAT-1 Peptide - 300115 from ABBIOTEC Category Peptide Prices $80.00 Sizes 100 µg

PAHT Blocking Peptide - CBP2385 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Monkey

OAT1 (L304) Peptide - BS3556P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

SLC22A6 protein - orb86184 from Biorbyt Category Protein Prices $238.00 Sizes 500 µg

SLC22A6 protein - orb86185 from Biorbyt Category Protein

SLC22A6 Protein Lysate - orb333425 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

SLC22A6 Peptide, Human - M34GP14393H from Creative Peptides Category Peptide Source Synthetic. Species Human

SLC22A6 Protein Lysate - orb333424 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

SLC22A6 Protein Lysate - orb333423 from Biorbyt Category Protein Prices $400.00 Sizes 200 μg Species Human

SLC22A6 peptide - orb12898 from Biorbyt Category Peptide Prices $170.00 Sizes 1 mg

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