PDGFD

Gene Symbol	PDGFD
Entrez Gene	80310
Alt Symbol	IEGF, MSTP036, SCDGF-B, SCDGFB
Species	Human
Gene Type	protein-coding
Description	platelet derived growth factor D
Other Description	PDGF-D|iris-expressed growth factor|platelet-derived growth factor D|spinal cord derived growth factor B|spinal cord-derived growth factor B|spinal cord-derived growth factor-B
Swissprots	Q9BWV5 A8K9T6 Q9GZP0
Accessions	CAH23468 CAT16765 CBJ57251 EAW67045 EAW67046 Q9GZP0 AB033832 BAB18903 AF113216 AAG39287 AF335584 AAK38840 AF336376 AAK56136 AI962915 AK292801 BAF85490 AY027517 AAK20081 AY027518 AAK20082 AY359116 AAQ89474 BC030645 AAH30645 BG722948 JF432532 ADZ15749 NM_025208 NP_079484 NM_033135 NP_149126
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
Tissue Specificity	Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. {EC
Top Pathways	Rap1 signaling pathway, Focal adhesion, Choline metabolism in cancer, PI3K-Akt signaling pathway, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

PDGF-D (E-3) - sc-137030 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDGF-D (E-6) - sc-137031 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDGF-D (E-7) - sc-137029 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

PDGF-D (H-140) - sc-30196 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PDGF-D (R-20) - sc-23573 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-SCDGFB antibody - ab169049 from Abcam Host Mouse Clonality Polyclonal

Anti-SCDGFB antibody - ab94782 from Abcam Prices $370.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-SCDGFB antibody [EPR7266(2)] - ab181845 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR7266(2)

Anti-SCDGFB antibody - C-terminal - ab190614 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (aa328-341) - LS-C3141 from LifeSpan Bioscience Prices $285.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (Internal, AP) - LS-C281075 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (Internal, APC) - LS-C281076 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (aa250-370, clone 11n152) - LS-C184871 from LifeSpan Bioscience Prices $575.00 Sizes 500 µg Host Mouse Clonality Monoclonal Clone 11n152

Anti-PDGF-D Antibody (Internal, Biotin) - LS-C281077 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (Internal, FITC) - LS-C281078 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (Internal, Azide-free, HRP) - LS-C281079 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (Internal, PE) - LS-C281080 from LifeSpan Bioscience Prices $515.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (Internal) - LS-C330589 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (aa253-370) - LS-C346434 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

Anti-PDGF-D Antibody (aa35-84) - LS-C110927 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PDGF-D Antibody (aa19-247, clone 1C1) - LS-C337519 from LifeSpan Bioscience Prices $350.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1C1

PDGF-D/SCDGFB Antibody - AF1159 from Novus Biologicals Prices $99.00, $359.00 Sizes 25 µg, 100 µg Host Goat Clonality Polyclonal

PDGF-D/SCDGFB Antibody - NBP1-59319 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

PDGF-D/SCDGFB Antibody (1C1) - NBP2-01332 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone 1C1

PDGF-D/SCDGFB Antibody - NBP2-38087 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

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