| Gene Symbol |
PDGFD
|
| Entrez Gene |
80310
|
| Alt Symbol |
IEGF, MSTP036, SCDGF-B, SCDGFB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
platelet derived growth factor D
|
| Other Description |
PDGF-D|iris-expressed growth factor|platelet-derived growth factor D|spinal cord derived growth factor B|spinal cord-derived growth factor B|spinal cord-derived growth factor-B
|
| Swissprots |
Q9BWV5 A8K9T6 Q9GZP0
|
| Accessions |
CAH23468 CAT16765 CBJ57251 EAW67045 EAW67046 Q9GZP0 AB033832 BAB18903 AF113216 AAG39287 AF335584 AAK38840 AF336376 AAK56136 AI962915 AK292801 BAF85490 AY027517 AAK20081 AY027518 AAK20082 AY359116 AAQ89474 BC030645 AAH30645 BG722948 JF432532 ADZ15749 NM_025208 NP_079484 NM_033135 NP_149126
|
| Function |
Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
|
| Tissue Specificity |
Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. {EC
|
| Top Pathways |
Rap1 signaling pathway, Focal adhesion, Choline metabolism in cancer, PI3K-Akt signaling pathway, Prostate cancer
|
![Western Blot: SCDGFB Overexpression Lysate (Adult Normal) [NBL1-14238] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SCDGFB.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/8696_SCDGFB%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-14238-img0002.jpg)