PDGFD

Gene Symbol	PDGFD
Entrez Gene	80310
Alt Symbol	IEGF, MSTP036, SCDGF-B, SCDGFB
Species	Human
Gene Type	protein-coding
Description	platelet derived growth factor D
Other Description	PDGF-D|iris-expressed growth factor|platelet-derived growth factor D|spinal cord derived growth factor B|spinal cord-derived growth factor B|spinal cord-derived growth factor-B
Swissprots	Q9BWV5 A8K9T6 Q9GZP0
Accessions	CAH23468 CAT16765 CBJ57251 EAW67045 EAW67046 Q9GZP0 AB033832 BAB18903 AF113216 AAG39287 AF335584 AAK38840 AF336376 AAK56136 AI962915 AK292801 BAF85490 AY027517 AAK20081 AY027518 AAK20082 AY359116 AAQ89474 BC030645 AAH30645 BG722948 JF432532 ADZ15749 NM_025208 NP_079484 NM_033135 NP_149126
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
Tissue Specificity	Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. {EC
Top Pathways	Rap1 signaling pathway, Focal adhesion, Choline metabolism in cancer, PI3K-Akt signaling pathway, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human PDGF-D ELISA Kit (Sandwich ELISA) - LS-F6349 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 12.5 pg/ml Range 12.5-800 pg/ml

Rat PDGF-D ELISA Kit (Sandwich ELISA) - LS-F9363 from LifeSpan Bioscience Category ELISA Kit Prices $780.00 Sizes 1 plate Sensitivity 0.125 ng/ml Range 12.5-800 pg/ml

Human PDGF-DD Quantikine ELISA Kit - DDD00 from R&D Systems Category ELISA Kit Prices $519.00 Sizes 1 kit Sensitivity 3.51 pg/mL Range 31.3 - 2,000 pg/mL (Cell Culture Supernates, Serum, Platelet-poor EDTA Plasma, Platelet-poor Heparin Plasma, Saliva, Human Milk)

Quantikine Immunoassay Control Set 725 for Human PDGF-DD - QC140 from R&D Systems Category ELISA Kit Prices $125.00 Sizes 1 each

Human PDGF-DD DuoSet ELISA - DY1159-05 from R&D Systems Category ELISA Kit Prices $299.00 Sizes 1 kit (for 5 Plates) Range 7.81 - 500 pg/mL

Human PDGFD ELISA Kit - abx152680 from Abbexa Category ELISA Kit Sensitivity 5.1 pg/ml Range 12.5 pg/ml - 800 pg/ml

Platelet Derived Growth Factor D, PDGFD, Human, ELISA Kit - E-EL-H2213 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 7.5 Range 12.5-800pg/mL

Platelet Derived Growth Factor D (PDGFD), Human, ELISA Kit - SEC919Hu from ARP American Research Products Category ELISA Kit Prices $720.00 Sizes 96 t Sensitivity 4.7pg/mL Range 12.5-800pg/mL

Platelet Derived Growth Factor D, Human, ELISA Kit - E01P0075 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 2.5-50ng/mL,

Platelet-derived growth factor D, PDGFD, Human, ELISA Kit - E1896h from ARP American Research Products Category ELISA Kit Prices $476.00 Sizes 96 t Range 15.6-1000 pg/mL

Platelet Derived Growth Factor D, PDGFD, Mouse, ELISA Kit - E-EL-M0921 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 9.375 Range 15.625-1000pg/mL

Platelet Derived Growth Factor D, PDGF-D, Rat, ELISA Kit - E-EL-R0755 from ARP American Research Products Category ELISA Kit Prices $686.00 Sizes 96 t

Platelet Derived Growth Factor D, PDGFD, Rabbit, ELISA Kit - E-EL-RB2154 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Platelet Derived Growth Factor D, PDGFD, Chicken, ELISA Kit - E-EL-Ch0059 from ARP American Research Products Category ELISA Kit Prices $445.50 Sizes 96 t

Platelet Derived Growth Factor D, PDGFD, Porcine, ELISA Kit - E-EL-P0748 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Platelet Derived Growth Factor D, PDGFD, Sheep, ELISA Kit - E-EL-S0689 from ARP American Research Products Category ELISA Kit Prices $648.00 Sizes 96 t

Platelet Derived Growth Factor D, PDGFD, Guinea Pig, ELISA Kit - E-EL-GP0595 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t

Platelet Derived Growth Factor D, PDGFD, Monkey, ELISA Kit - E-EL-MK1021 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Platelet Derived Growth Factor D (PDGFD), Human, CLIA Kit - SCC919Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.201ng/mL Range 0.625-40ng/mL

PDGFD (Human) IP-WB Antibody Pair - H00080310-PW2 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

PDGFD (Human) IP-WB Antibody Pair - H00080310-PW3 from Acris Antibodies Category Antibody Pair Prices $610.00 Sizes 1 set

Human PDGFD ELISA Kit - HP0082 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine PDGFD ELISA Kit - AP0082 from NeoScientific Category ELISA Kit Prices $300.00, $480.00 Sizes 100 µl, 200 µl

Human PDGF-D(Platelet Derived Growth Factor D) ELISA Kit - E-EL-H2213 from Elabscience Category ELISA Kit Sensitivity 7.50 pg/mL Range 12.50—800 pg/mL

Human PDGFD (Platelet Derived Growth Factor D) CLIA Kit - E-CL-H1309 from Elabscience Category CLIA Kit Sensitivity 4.69 pg/mL Range Average Recovery (%)

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