PDGFD

Gene Symbol	PDGFD
Entrez Gene	80310
Alt Symbol	IEGF, MSTP036, SCDGF-B, SCDGFB
Species	Human
Gene Type	protein-coding
Description	platelet derived growth factor D
Other Description	PDGF-D|iris-expressed growth factor|platelet-derived growth factor D|spinal cord derived growth factor B|spinal cord-derived growth factor B|spinal cord-derived growth factor-B
Swissprots	Q9BWV5 A8K9T6 Q9GZP0
Accessions	CAH23468 CAT16765 CBJ57251 EAW67045 EAW67046 Q9GZP0 AB033832 BAB18903 AF113216 AAG39287 AF335584 AAK38840 AF336376 AAK56136 AI962915 AK292801 BAF85490 AY027517 AAK20081 AY027518 AAK20082 AY359116 AAQ89474 BC030645 AAH30645 BG722948 JF432532 ADZ15749 NM_025208 NP_079484 NM_033135 NP_149126
Function	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including influx of monocytes and macrophages and production of extracellular matrix (By similarity). {ECO:0000250}.
Subcellular Location	Secreted {ECO:0000269|PubMed:11331882}. Note=Released by platelets upon wounding.
Tissue Specificity	Expressed at high levels in the heart, pancreas, adrenal gland and ovary and at low levels in placenta, liver, kidney, prostate, testis, small intestine, spleen and colon. In the kidney, expressed by the visceral epithelial cells of the glomeruli. A widespread expression is also seen in the medial smooth muscle cells of arteries and arterioles, as well as in smooth muscle cells of vasa rectae in the medullary area. Expressed in the adventitial connective tissue surrounding the suprarenal artery. In chronic obstructive nephropathy, a persistent expression is seen in glomerular visceral epithelial cells and vascular smooth muscle cells, as well as de novo expression by periglomerular interstitial cells and by some neointimal cells of atherosclerotic vessels. Expression in normal prostate is seen preferentially in the mesenchyme of the gland while expression is increased and more profuse in prostate carcinoma. Expressed in many ovarian, lung, renal and brain cancer-derived cell lines. {EC
Top Pathways	Rap1 signaling pathway, Focal adhesion, Choline metabolism in cancer, PI3K-Akt signaling pathway, Prostate cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SCDGFB protein fragment - ab134520 from Abcam Category Protein Source E. coli Species Human

PDGF-D Antibody Blocking Peptide - LS-E21522 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PDGF-D/SCDGFB Recombinant Protein - H00080310-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

PDGF-D/SCDGFB Partial Recombinant Protein - H00080310-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Recombinant Human PDGF-D/SCDGFB Protein - NBP2-23335 from Novus Biologicals Category Protein Prices $269.00 Sizes 100 µg Source E.coli Species Human

Recombinant Human PDGF-DD - 1159-SB-025 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser250-Arg370

Recombinant Human PDGF-DD, CF - 1159-SB-025/CF from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived, Ser250-Arg370

Human PDGFD protein - orb169002 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Source E.coli

PDGFD Blocking Peptide - 33R-6641 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PDGFD protein (His tag) - 80R-2463 from Fitzgerald Category Protein Prices $270.00 Sizes 100 µg Source E.coli

PDGFD (250-370, His-tag) - AR50535PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PDGFD (250-370, His-tag) - AR50535PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PDGFD - H00080310-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

PDGFD - H00080310-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

PDGFD - H00080310-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

PDGFD - H00080310-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

PDGFD, 250-370aa, Human, His tag, E.coli - 01-P1711 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

PDGFD fusion protein - Ag5154 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

PDGFD fusion protein - Ag7430 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET20b Species Human

PDGFD Human - CYPS-162 from NeoScientific Category Protein Prices $65.00, $169.00, $3,510.00 Sizes 5 µg, 20 µg, 1 mg Source E.coli. Species Human

PDGFD, 250-370aa, Recombinant Protein - GWB-P0327B from Genway Biotech Category Protein Prices $300.00, $900.00 Sizes 100 μg, 500 μg Source E.coli Species Human

Recombinant Human PDGFD, His tagged - PDGFD-207H from Creative Biomart Category Protein Source Human Cells Species Human

Recombinant Human PDGFD - PDGFD-211H from Creative Biomart Category Protein Source Mouse NSO Cells

Recombinant Human PDGFD, His-tagged - PDGFD-1611H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human Platelet Derived Growth Factor D, His-tagged - PDGFD-7140H from Creative Biomart Category Protein Source E. coli Species Human

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