| Gene Symbol |
TRPV5
|
| Entrez Gene |
56302
|
| Alt Symbol |
CAT2, ECAC1, OTRPC3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transient receptor potential cation channel, subfamily V, member 5
|
| Other Description |
calcium transport protein 2|calcium transporter 2|epithelial calcium channel 1|osm-9-like TRP channel 3|transient receptor potential cation channel subfamily V member 5
|
| Swissprots |
Q8NDX8 E9PBZ6 Q9NQA5 Q8NDX7 A4D2H7 Q8NDW5 Q8N4C1 Q96PM6
|
| Accessions |
AAO13488 CAC08182 EAL23777 EAW51896 Q9NQA5 AF304464 AAL04015 AJ271207 CAB96365 AJ487965 CAD32312 BC034740 AAH34740 NM_019841 NP_062815
|
| Function |
Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. {ECO:0000250}.
|
| Tissue Specificity |
Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO:0000269|PubMed:10945469, ECO:0000269|PubMed:11549322}.
|
| Top Pathways |
Endocrine and other factor-regulated calcium reabsorption
|