TRPV5

Gene Symbol	TRPV5
Entrez Gene	56302
Alt Symbol	CAT2, ECAC1, OTRPC3
Species	Human
Gene Type	protein-coding
Description	transient receptor potential cation channel, subfamily V, member 5
Other Description	calcium transport protein 2|calcium transporter 2|epithelial calcium channel 1|osm-9-like TRP channel 3|transient receptor potential cation channel subfamily V member 5
Swissprots	Q8NDX8 E9PBZ6 Q9NQA5 Q8NDX7 A4D2H7 Q8NDW5 Q8N4C1 Q96PM6
Accessions	AAO13488 CAC08182 EAL23777 EAW51896 Q9NQA5 AF304464 AAL04015 AJ271207 CAB96365 AJ487965 CAD32312 BC034740 AAH34740 NM_019841 NP_062815
Function	Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.
Subcellular Location	Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. {ECO:0000250}.
Tissue Specificity	Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO:0000269|PubMed:10945469, ECO:0000269|PubMed:11549322}.
Top Pathways	Endocrine and other factor-regulated calcium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human TRPV5 peptide - ab93367 from Abcam Category Peptide Species Human

Human TRPV5 peptide - ab93372 from Abcam Category Peptide Species Human

Human TRPV5 protein fragment - ab153420 from Abcam Category Protein Source Wheat germ Species Human

ECaC / TRPV5 Antibody Blocking Peptide - LS-E4449 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ECaC / TRPV5 Antibody Blocking Peptide - LS-E17850 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ECaC / TRPV5 Antibody Blocking Peptide - LS-E26703 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

TRPV5 Partial Recombinant Protein - H00056302-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

TRPV5 Peptide - NB110-74953PEP from Novus Biologicals Category Peptide Prices $259.00 Sizes 50 µg

TRPV5-Antibody-C-term-Blocking-Peptide - BP16764b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TRPV5 blocking peptide - GTX88774-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Rat

TRPV5 Blocking Peptide - 33R-6206 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TRPV5 Peptide - AC21-1542-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TRPV5 / ECAC1 - H00056302-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TRPV5 / ECAC1 - H00056302-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TRPV5 Peptide - 46-533P from ProSci Category Peptide Species Human

TRPV5 fusion protein - ag11298 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TRPV5 fusion protein - Ag11326 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

TRPV5, Peptide - MBS426896 from MyBioSource Category Peptide Prices $175.00 Sizes 100 µg Species Human, Mouse, Rat, Dog, Pig, Bovine

TRPV5 Recombinant Protein Antigen - NBP2-49386PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

TRPV5 Peptide, Human - M34GP16693H from Creative Peptides Category Peptide Source Synthetic. Species Human

TRPV5 peptide - orb14353 from Biorbyt Category Peptide Prices $170.00 Sizes 1 mg

TRPV5 Immunizing peptide - orb17397 from Biorbyt Category Peptide

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