TRPV5

Gene Symbol TRPV5
Entrez Gene 56302
Alt Symbol CAT2, ECAC1, OTRPC3
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 5
Other Description calcium transport protein 2|calcium transporter 2|epithelial calcium channel 1|osm-9-like TRP channel 3|transient receptor potential cation channel subfamily V member 5
Swissprots Q8NDX8 E9PBZ6 Q9NQA5 Q8NDX7 A4D2H7 Q8NDW5 Q8N4C1 Q96PM6
Accessions AAO13488 CAC08182 EAL23777 EAW51896 Q9NQA5 AF304464 AAL04015 AJ271207 CAB96365 AJ487965 CAD32312 BC034740 AAH34740 NM_019841 NP_062815
Function Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. {ECO:0000250}.
Tissue Specificity Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO:0000269|PubMed:10945469, ECO:0000269|PubMed:11549322}.
Top Pathways Endocrine and other factor-regulated calcium reabsorption

TRPV5 (B-6) - sc-398853 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
TRPV5 (B-6): sc-398853. Western blot analysis of TRPV5 expression in Caki-1 whole cell lysate.

TRPV5 (H-99) - sc-30186 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRPV5 (H-99): sc-30186. Western blot analysis of TRPV5 expression in Caki-1 (A), Hep G2 (B), H4 (C), MG-63 (D) and HOS (E) whole cell lysates.

TRPV5 (C-15) - sc-23376 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPV5 (K-17) - sc-23375 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

TRPV5 (R-98) - sc-30187 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
TRPV5 (R-98): sc-30187. Western blot analysis of TRPV5 expression in Hep G2 whole cell lysate.

Anti-TRPV5 antibody - ab63085 from Abcam

Host Rabbit
Clonality Polyclonal
ab63085, staining TRPV5 in equine articular cartilage, by Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections). Sections were blocked with PBS-T and 1% BSA before incubating with primary antibody overnight at 4°C. An HRP-conjugated goat anti-rabbit IgG was used as the secondary antibody and was detected using DAB. Nuclei were counterstained with hematoxylin.

Anti-TRPV5 antibody - ab77351 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Anti-TRPV5 antibody (ab77351) at 1 µg/ml + Human pancreas lysate in RIPA buffer at 35 µg

Anti-TRPV5 antibody - ab57630 from Abcam

Prices $370.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-TRPV5 antibody (ab57630) + immunogen

Anti-TRPV5 antibody - ab64231 from Abcam

Host Sheep
Clonality Polyclonal

Anti-TRPV5 antibody - ab74713 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-TRPV5 antibody [EPR8875] - ab137028 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR8875
Overlay histogram showing HEK293 cells stained with ab137028 (red line). The cells were fixed with 80% methanol (5 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab137028, 1/10000 dilution) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-rabbit IgG (H&L) (ab150077) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was rabbit IgG (monoclonal) (0.1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter.

Anti-ECaC / TRPV5 Antibody (C-Terminus) - LS-C12356 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa634-663, AP) - LS-C242208 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa634-663, FITC) - LS-C242211 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa634-663, Biotin) - LS-C242210 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (4th Cytoplasmic Domain) - LS-C95032 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Sheep
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa634-663, APC) - LS-C242209 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa634-663, Azide-free, HRP) - LS-C247147 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa634-663, PE) - LS-C242213 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (aa633-663) - LS-C325992 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ECaC / TRPV5 Antibody (clone 6D6) - LS-C139065 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 6D6
TRPV5 monoclonal antibody (M06), clone 6D6. Western blot of TRPV5 expression in IMR-32.

Anti-ECaC / TRPV5 Antibody (aa38-87) - LS-C81386 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
721_B cell lysate. Antibody concentration: 1.0 ug/ml. Gel concentration: 12%.

Anti-ECaC / TRPV5 Antibody (aa697-708) - LS-C55634 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Antibody (1 ug/ml) staining of Human Pancreas lysate (35 ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ECaC / TRPV5 Antibody (aa634-663) - LS-C160239 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
TRPV5 Antibody western blot of HepG2 cell line lysates (35 ug/lane). The TRPV5 antibody detected the TRPV5 protein (arrow).

Anti-ECaC / TRPV5 Antibody - LS-C334742 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using TRPV5 antibody.
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