TRPV5

Gene Symbol TRPV5
Entrez Gene 56302
Alt Symbol CAT2, ECAC1, OTRPC3
Species Human
Gene Type protein-coding
Description transient receptor potential cation channel, subfamily V, member 5
Other Description calcium transport protein 2|calcium transporter 2|epithelial calcium channel 1|osm-9-like TRP channel 3|transient receptor potential cation channel subfamily V member 5
Swissprots Q8NDX8 E9PBZ6 Q9NQA5 Q8NDX7 A4D2H7 Q8NDW5 Q8N4C1 Q96PM6
Accessions AAO13488 CAC08182 EAL23777 EAW51896 Q9NQA5 AF304464 AAL04015 AJ271207 CAB96365 AJ487965 CAD32312 BC034740 AAH34740 NM_019841 NP_062815
Function Constitutively active calcium selective cation channel thought to be involved in Ca(2+) reabsorption in kidney and intestine. The channel is activated by low internal calcium level and the current exhibits an inward rectification. A Ca(2+)- dependent feedback regulation includes fast channel inactivation and slow current decay. Heteromeric assembly with TRPV6 seems to modify channel properties. TRPV5-TRPV6 heteromultimeric concatemers exhibit voltage-dependent gating (By similarity). {ECO:0000250}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:18768590}; Multi-pass membrane protein {ECO:0000269|PubMed:18768590}. Note=Colocalized with S100A10 and ANAX2 along the apical domain of kidney distal tubular cells (By similarity). The expression of the glycosylated form in the cell membrane is increased in the presence of WNK3. {ECO:0000250}.
Tissue Specificity Expressed at high levels in kidney, small intestine and pancreas, and at lower levels in testis, prostate, placenta, brain, colon and rectum. {ECO:0000269|PubMed:10945469, ECO:0000269|PubMed:11549322}.
Top Pathways Endocrine and other factor-regulated calcium reabsorption

TRPV5 CRISPR/Cas9 KO Plasmid (h) - sc-403668 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 HDR Plasmid (h) - sc-403668-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 Double Nickase Plasmid (h) - sc-403668-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 Double Nickase Plasmid (h2) - sc-403668-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 CRISPR Activation Plasmid (h) - sc-403668-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 CRISPR Activation Plasmid (h2) - sc-403668-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 Lentiviral Activation Particles (h) - sc-403668-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 Lentiviral Activation Particles (h2) - sc-403668-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

TRPV5 siRNA (h) - sc-42676 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV5 shRNA Plasmid (h) - sc-42676-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV5 shRNA (h) Lentiviral Particles - sc-42676-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

TRPV5 RNAi - H00056302-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

CompoZr® Knockout ZFN Kit - CKOZFN22066 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND22066 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

TRPV5 siRNA (Human) - CRJ1134 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

TRPV5 - MBS8236715 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human TRPV5 (NM_019841.4) - SHH435792 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human TRPV5(NM_019841.4) - SHL098128 from Creative biogene

Category siRNA
Species Reactivities Human

TRPV5 shRNA Plasmid (Human) - CHJ1134 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

TRPV5 miRNA 3'UTR clone - MiUTR1H-10795 from Creative biogene

Species Reactivities Human
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