Gene Symbol | VCAM1 |
---|---|
Entrez Gene | 7412 |
Alt Symbol | CD106, INCAM-100 |
Species | Human |
Gene Type | protein-coding |
Description | vascular cell adhesion molecule 1 |
Other Description | CD106 antigen|vascular cell adhesion protein 1 |
Swissprots | E9PDD1 A8K6R7 P19320 Q6NUP8 B4DKS4 |
Accessions | AAA61270 AAM96190 ADZ72971 AEH21939 AEH21940 AEL21381 AEL30503 EAW72949 EAW72950 P19320 AK223266 BAD96986 AK291732 BAF84421 AK296692 BAG59286 AU121762 BC017276 AAH17276 BC068490 AAH68490 BC085003 AAH85003 BF791565 BF968655 CR749464 CAH18296 DB096825 EU831989 ACE87430 EU832082 ACE86744 M30257 AAA51917 M60335 AAA61269 X53051 CAA37218 NM_001078 NP_001069 NM_001199834 NP_001186763 NM_080682 NP_542413 |
Function | Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha-4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. |
Subcellular Location | Membrane; Single-pass type I membrane protein. |
Tissue Specificity | Expressed on inflammed vascular endothelium, as well as on macrophage-like and dendritic cell types in both normal and inflammed tissue. |
Top Pathways | Leukocyte transendothelial migration, Cell adhesion molecules (CAMs), Malaria, African trypanosomiasis, HTLV-I infection |