PABPN1

Gene Symbol PABPN1
Entrez Gene 8106
Alt Symbol OPMD, PAB2, PABII, PABP-2, PABP2
Species Human
Gene Type protein-coding
Description poly(A) binding protein, nuclear 1
Other Description poly(A) binding protein 2|poly(A) binding protein II|polyadenylate-binding protein 2
Swissprots O43484 Q86U42 D3DS49
Accessions AAC39596 EAW66167 EAW66168 Q86U42 AK293633 BAG57089 BC010939 AAH10939 BI830835 BM979311 BX247976 CAD62310 NM_004643 NP_004634
Function Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). {ECO:0000250}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250}.
Tissue Specificity Ubiquitous.
Top Pathways mRNA surveillance pathway, Influenza A

Polyadenylate-binding protein 2, ELISA Kit - MBS280784 from MyBioSource

Category ELISA Kit
Prices $425.00, $720.00, $3,160.00, $6,055.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 7.8 pg/mL (mean of 6 independent assays).
Range 15.6 pg/mL - 1000 pg/mL.

Human PABPN1 ELISA Kit - E030040 from Biobool

Category ELISA Kit
Sensitivity 7.8 pg/mL (mean of 6 independent assays)

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393762 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393770 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393755 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393758 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393756 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393757 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393761 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393766 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393759 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393763 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393765 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393764 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393760 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393767 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393768 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393769 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393771 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393772 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393773 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Polyadenylate-Binding Protein 2 (PABP2), ELISA Kit - MBS9393774 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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