| Gene Symbol |
PABPN1
|
| Entrez Gene |
8106
|
| Alt Symbol |
OPMD, PAB2, PABII, PABP-2, PABP2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
poly(A) binding protein, nuclear 1
|
| Other Description |
poly(A) binding protein 2|poly(A) binding protein II|polyadenylate-binding protein 2
|
| Swissprots |
O43484 Q86U42 D3DS49
|
| Accessions |
AAC39596 EAW66167 EAW66168 Q86U42 AK293633 BAG57089 BC010939 AAH10939 BI830835 BM979311 BX247976 CAD62310 NM_004643 NP_004634
|
| Function |
Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|
| Top Pathways |
mRNA surveillance pathway, Influenza A
|