PABPN1

Gene Symbol	PABPN1
Entrez Gene	8106
Alt Symbol	OPMD, PAB2, PABII, PABP-2, PABP2
Species	Human
Gene Type	protein-coding
Description	poly(A) binding protein, nuclear 1
Other Description	poly(A) binding protein 2|poly(A) binding protein II|polyadenylate-binding protein 2
Swissprots	O43484 Q86U42 D3DS49
Accessions	AAC39596 EAW66167 EAW66168 Q86U42 AK293633 BAG57089 BC010939 AAH10939 BI830835 BM979311 BX247976 CAD62310 NM_004643 NP_004634
Function	Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	mRNA surveillance pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

PABP2 (D6F3Q) Rabbit mAb - 14154 from Cell Signaling Technology Prices $99.00, $246.00 Sizes 20 µl (2 western blots), 100 µl (10 western blots) Host Rabbit Clonality Monoclonal Clone D6F3Q

PABPN1 (G-17) - sc-33007 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

PABPN1 (H-46) - sc-67017 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

PABPN1 (K-18) - sc-33009 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-PABP2 antibody [EP3001Y] - ab81224 from Abcam Prices $357.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP3001Y

Anti-PABPN1 antibody - ab130654 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 antibody [EP3000Y] - ab75855 from Abcam Prices $401.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP3000Y

Anti-PABPN1 / PABP2 Antibody (aa270-298, AP) - LS-C238622 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa270-298, APC) - LS-C238623 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa270-298, Biotin) - LS-C238624 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa270-298, PE) - LS-C238626 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa270-298, Azide-free, HRP) - LS-C248389 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa1-50) - LS-C290195 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa270-298, FITC) - LS-C238625 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa100-150) - LS-C290196 from LifeSpan Bioscience Prices $375.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa269-298) - LS-C323751 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (aa270-298) - LS-C163334 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (Internal, clone EP3001Y) IHC-plus™ - LS-B8482 from LifeSpan Bioscience Prices $395.00 Sizes 50 µl Host Rabbit Clonality Monoclonal Clone EP3001Y

Anti-PABPN1 / PABP2 Antibody - LS-C334482 from LifeSpan Bioscience Prices $315.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-PABPN1 / PABP2 Antibody (N-Terminus, clone EP3000Y) - LS-C105388 from LifeSpan Bioscience Prices $505.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EP3000Y

Anti-PABPN1 / PABP2 Antibody (N-Terminus) IHC-plus™ - LS-B5706 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

PABPN1 Antibody - NBP1-57216 from Novus Biologicals Prices $139.00, $329.00 Sizes 20 µl, 100 µl Host Rabbit Clonality Polyclonal

PABPN1 Antibody - NBP1-31805 from Novus Biologicals Prices $329.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-BCL2L2-PABPN1 antibody produced in rabbit - HPA000637 from Sigma-Aldrich Prices $429.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-PABPN1, (N-terminal) antibody produced in rabbit - SAB2104546 from Sigma-Aldrich Prices $347.50 Sizes 100 µl Host Rabbit Clonality Polyclonal

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