PABPN1

Gene Symbol	PABPN1
Entrez Gene	8106
Alt Symbol	OPMD, PAB2, PABII, PABP-2, PABP2
Species	Human
Gene Type	protein-coding
Description	poly(A) binding protein, nuclear 1
Other Description	poly(A) binding protein 2|poly(A) binding protein II|polyadenylate-binding protein 2
Swissprots	O43484 Q86U42 D3DS49
Accessions	AAC39596 EAW66167 EAW66168 Q86U42 AK293633 BAG57089 BC010939 AAH10939 BI830835 BM979311 BX247976 CAD62310 NM_004643 NP_004634
Function	Involved in the 3'-end formation of mRNA precursors (pre-mRNA) by the addition of a poly(A) tail of 200-250 nt to the upstream cleavage product. Stimulates poly(A) polymerase (PAPOLA) conferring processivity on the poly(A) tail elongation reaction and controls also the poly(A) tail length. Increases the affinity of poly(A) polymerase for RNA. Is also present at various stages of mRNA metabolism including nucleocytoplasmic trafficking and nonsense-mediated decay (NMD) of mRNA. Cooperates with SKIP to synergistically activate E-box-mediated transcription through MYOD1 and may regulate the expression of muscle-specific genes. Binds to poly(A) and to poly(G) with high affinity. May protect the poly(A) tail from degradation (By similarity). {ECO:0000250}.
Subcellular Location	Nucleus {ECO:0000250}. Cytoplasm {ECO:0000269|PubMed:10688363, ECO:0000269|PubMed:11001936, ECO:0000269|PubMed:14663186, ECO:0000269|PubMed:17289661}. Note=Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Shuttles between the nucleus and the cytoplasm but predominantly found in the nucleus. Its nuclear import may involve the nucleocytoplasmic transport receptor transportin and a RAN-GTP-sensitive import mechanism. Is exported to the cytoplasm by a carrier-mediated pathway that is independent of mRNA traffic. Nucleus; nuclear speckle. Colocalizes with SKIP and poly(A) RNA in nuclear speckles (By similarity). {ECO:0000250}.
Tissue Specificity	Ubiquitous.
Top Pathways	mRNA surveillance pathway, Influenza A

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• Cell/Tissue/Blood Products

Human PABPN1 protein fragment - ab177635 from Abcam Category Protein Source E. coli Species Human

PABPN1 / PABP2 Antibody Blocking Peptide - LS-E4508 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PABPN1 / PABP2 Antibody Blocking Peptide - LS-E14814 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

PABPN1-Antibody-C-term-Blocking-Peptide - BP16835b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

PABPN1 Blocking Peptide - 33R-5580 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

PABPN1 protein (His tag) - 80R-3633 from Fitzgerald Category Protein Prices $275.00 Sizes 100 µg Source E.coli

PABPN1 (119-306, His-tag) - AR51320PU-N from Acris Antibodies Category Protein Prices $790.00 Sizes 500 µg Source E. coli Species Human

PABPN1 (119-306, His-tag) - AR51320PU-S from Acris Antibodies Category Protein Prices $340.00 Sizes 100 µg Source E. coli Species Human

PABPN1, 119-306aa, Human, His tag, E.coli - 01-P2500 from ARP American Research Products Category Protein Prices $179.00, $369.00, $849.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Recombinant Human PABPN1, His-tagged - PABPN1-5004H from Creative Biomart Category Protein Source E. coli Species Human

Recombinant Human poly(A) binding protein, nuclear 1, His-tagged - PABPN1-403H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human PABPN1 - PABPN1-586H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Polyadenylate-binding Protein 2 - CBCRY37 from Creative Biomart Category Protein Source E.coli

Recombinant Human Polyadenylate-binding protein 2(PABPN1) - CSB-YP768207HU CSB-EP768207HU CSB-BP768207HU CSB-MP768207HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

PABPN1, 119-306aa, Human, His tag, E.coli (Denatured) - ATGP2500 from ATGen Category Protein Prices $80.00, $240.00, $720.00 Sizes 20 µg, 100 µg, 500 µg Species Human

PABPN1, Recombinant Protein - MBS205594 from MyBioSource Category Protein Prices $310.00, $720.00 Sizes 100 µg, 500 µg Source E Coli Species Human

Polyadenylate-binding protein 2 (PABPN1), Recombinant Protein - MBS1334326 from MyBioSource Category Protein Prices $1,065.00, $1,065.00, $1,290.00, $1,290.00, $1,660.00, $1,660.00, $2,125.00, $2,125.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

PABPN1 Recombinant Protein Antigen - NBP1-82481PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

Human PABPN1 protein - orb259997 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 20 μg Species Human

PABPN1 Peptide, Human - M34GP11228H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant Human PABPN1 Protein - NBP2-51516 from Novus Biologicals Category Protein Prices $259.00, $759.00 Sizes 100 µg, 500 µg Source E. coli Species Human

PABPN1 - PAT-82499-1 from Nordic BioSite Category Protein Species Human

PABPN1 - PAT-82499-2 from Nordic BioSite Category Protein Species Human

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