| Gene Symbol |
MAP2K5
|
| Entrez Gene |
5607
|
| Alt Symbol |
HsT17454, MAPKK5, MEK5, PRKMK5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
mitogen-activated protein kinase kinase 5
|
| Other Description |
MAP kinase kinase 5|MAP kinase kinase MEK5b|MAPK/ERK kinase 5|MAPKK 5|MEK 5|dual specificity mitogen-activated protein kinase kinase 5
|
| Swissprots |
B4DE43 Q13163 Q92962 Q92961
|
| Accessions |
CBX51412 EAW77799 EAW77800 EAW77801 EAW77802 Q13163 AK024766 AK057521 BAG51927 AK293459 BAG56954 AK315435 BAG37823 BC008838 AAH08838 BI460343 BM682675 BT006780 AAP35426 CR542229 CAG47025 DN998338 JF432129 ADZ15346 U71087 AAB16851 U71088 AAB16852 XM_011521784 XP_011520086 XM_011521785 XP_011520087 XM_011521786 XP_011520088 XM_011521787 XP_011520089 XM_011521788 XP_011520090 NM_001206804 NP_001193733 NM_002757 NP_002748 NM_145160 NP_660143 NM_145161 NM_145162
|
| Function |
Acts as a scaffold for the formation of a ternary MAP3K2/MAP3K3-MAP3K5-MAPK7 signaling complex. Activation of this pathway appears to play a critical role in protecting cells from stress-induced apoptosis, neuronal survival and cardiac development and angiogenesis. {ECO:0000269|PubMed:7759517, ECO:0000269|PubMed:9384584}.
|
| Tissue Specificity |
Expressed in many adult tissues. Abundant in heart and skeletal muscle.
|
| Top Pathways |
Gap junction, MAPK signaling pathway, Neurotrophin signaling pathway, Oxytocin signaling pathway
|
![Western Blot: MEK5 Overexpression Lysate (Adult Normal) [NBP2-05497] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for MEK5.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/17448_MEK5%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBP2-05497-img0001.jpg)