NPRL2

Gene Symbol	NPRL2
Entrez Gene	10641
Alt Symbol	NPR2, NPR2L, TUSC4
Species	Human
Gene Type	protein-coding
Description	nitrogen permease regulator-like 2 (S. cerevisiae)
Other Description	2810446G01Rik|G21 protein|NPR2-like protein|gene 21 protein|homologous to yeast nitrogen permease (candidate tumor suppressor)|nitrogen permease regulator 2-like protein|tumor suppressor candidate 4
Swissprots	Q9Y249 Q6FGS2 A8K831 Q9Y497 Q8WTW4
Accessions	AAB67310 EAW65106 EAW65107 EAW65108 EAW65109 EAW65110 EAW65111 EAW65112 Q8WTW4 AF040707 AAC62535 AF040708 AAC62536 AK098161 AK292196 BAF84885 AK309658 AL833426 BC008802 BC021984 AAH21984 BC050412 BC056861 AAH56861 BC063030 CR542035 CAG46832 XM_005264806 XP_005264863 XM_005264808 XP_005264865 XM_011533287 XP_011531589 XM_011533288 XP_011531590 XM_011533289 XP_011531591 XR_940364 NM_006545 NP_006536
Function	Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. {ECO:0000269|PubMed:18616680, ECO:0000269|PubMed:23723238}.
Tissue Specificity	Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NPRL2 (F-3) - sc-376986 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NPRL2 (C-20) - sc-54638 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

NPRL2 (H-300) - sc-292095 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

NPRL2 (H-8) - sc-166969 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

NPRL2 (N-18) - sc-54487 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

Anti-NPR2L antibody - ab192331 from Abcam Prices $370.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NPR2L antibody - ab88691 from Abcam Prices $370.00 Sizes 50 µg Host Mouse Clonality Polyclonal

Anti-NPR2L antibody - N-terminal - ab189852 from Abcam Prices $370.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody - LS-C334346 from LifeSpan Bioscience Prices $255.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (N-Terminus) IHC-plus™ - LS-B9747 from LifeSpan Bioscience Prices $450.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373, AP) - LS-C264641 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373, APC) - LS-C264642 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373) - LS-C162968 from LifeSpan Bioscience Prices $295.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373, Biotin) - LS-C264643 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373, FITC) - LS-C264644 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373, Azide-free, HRP) - LS-C264645 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa346-373, PE) - LS-C264646 from LifeSpan Bioscience Prices $545.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa345-373) - LS-C323421 from LifeSpan Bioscience Prices $345.00 Sizes 200 µl Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa287-336) - LS-C107970 from LifeSpan Bioscience Prices $365.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody - LS-C341912 from LifeSpan Bioscience Prices $385.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-NPR2L / TUSC4 Antibody (aa140-151) - LS-C55639 from LifeSpan Bioscience Prices $395.00 Sizes 100 µg Host Goat Clonality Polyclonal

TUSC4 Antibody - NBP1-82537 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TUSC4 Antibody - NBP1-79375 from Novus Biologicals Prices $369.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

Natriuretic Peptide Receptor B Antibody - NBP1-82538 from Novus Biologicals Prices $419.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

TUSC4 Antibody - H00010641-B01P from Novus Biologicals Prices $359.00 Sizes 50 µg Host Mouse Clonality Polyclonal

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