NPRL2

Gene Symbol	NPRL2
Entrez Gene	10641
Alt Symbol	NPR2, NPR2L, TUSC4
Species	Human
Gene Type	protein-coding
Description	nitrogen permease regulator-like 2 (S. cerevisiae)
Other Description	2810446G01Rik|G21 protein|NPR2-like protein|gene 21 protein|homologous to yeast nitrogen permease (candidate tumor suppressor)|nitrogen permease regulator 2-like protein|tumor suppressor candidate 4
Swissprots	Q9Y249 Q6FGS2 A8K831 Q9Y497 Q8WTW4
Accessions	AAB67310 EAW65106 EAW65107 EAW65108 EAW65109 EAW65110 EAW65111 EAW65112 Q8WTW4 AF040707 AAC62535 AF040708 AAC62536 AK098161 AK292196 BAF84885 AK309658 AL833426 BC008802 BC021984 AAH21984 BC050412 BC056861 AAH56861 BC063030 CR542035 CAG46832 XM_005264806 XP_005264863 XM_005264808 XP_005264865 XM_011533287 XP_011531589 XM_011533288 XP_011531590 XM_011533289 XP_011531591 XR_940364 NM_006545 NP_006536
Function	Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. {ECO:0000269|PubMed:18616680, ECO:0000269|PubMed:23723238}.
Tissue Specificity	Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human NPR2L full length protein - ab131926 from Abcam Category Protein Source Wheat germ Species Human

Human NPR2L peptide - ab22958 from Abcam Category Peptide Species Human

NPR2L / TUSC4 Antibody Blocking Peptide - LS-E4498 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NPR2L / TUSC4 Antibody Blocking Peptide - LS-E18246 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NPR2L / TUSC4 Antibody Blocking Peptide - LS-E26579 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NPR2L / TUSC4 Blocking Peptide - LS-E26580 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human TUSC4 Protein - H00010641-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Natriuretic Peptide Receptor B Protein - H00004882-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Recombinant Human Natriuretic Peptide Receptor B Protein - H00004882-P01 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Recombinant Human Natriuretic Peptide Receptor B Protein - H00004882-G01 from Novus Biologicals Category Protein Prices $569.00 Sizes 10 µg Source Wheat Germ Species Human

Natriuretic Peptide Receptor B Peptide - P3116 from Novus Biologicals Category Peptide Species Human

NPRL2-Antibody-C-term-Blocking-Peptide - BP16818b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

TUSC4/NPRL2 (aa 140 to 151) blocking peptide - GTX88896-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

TUSC4/NPRL2 (aa 269 to 280) blocking peptide - GTX88844-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

TUSC4 Immunizing peptide - orb50383 from Biorbyt Category Peptide Prices $247.00 Sizes 100 μg Species Human, Mouse, Rat

TUSC4 Blocking Peptide - 33R-8625 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

TUSC4 Blocking Peptide - 33R-6075 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

NPR2L Peptide - AC21-1415-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

NPR2L Peptide - AC21-1416-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

TUSC4 / NPRL2 - H00010641-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

TUSC4 / NPRL2 - H00010641-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

TUSC4 Peptide - 46-539P from ProSci Category Peptide Species Human

TUSC4 Peptide - 46-540P from ProSci Category Peptide Species Human

TUSC4 fusion protein - ag9372 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

TUSC4 fusion protein - ag9505 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

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