NPRL2
| Gene Symbol | NPRL2 |
|---|---|
| Entrez Gene | 10641 |
| Alt Symbol | NPR2, NPR2L, TUSC4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | nitrogen permease regulator-like 2 (S. cerevisiae) |
| Other Description | 2810446G01Rik|G21 protein|NPR2-like protein|gene 21 protein|homologous to yeast nitrogen permease (candidate tumor suppressor)|nitrogen permease regulator 2-like protein|tumor suppressor candidate 4 |
| Swissprots | Q9Y249 Q6FGS2 A8K831 Q9Y497 Q8WTW4 |
| Accessions | AAB67310 EAW65106 EAW65107 EAW65108 EAW65109 EAW65110 EAW65111 EAW65112 Q8WTW4 AF040707 AAC62535 AF040708 AAC62536 AK098161 AK292196 BAF84885 AK309658 AL833426 BC008802 BC021984 AAH21984 BC050412 BC056861 AAH56861 BC063030 CR542035 CAG46832 XM_005264806 XP_005264863 XM_005264808 XP_005264865 XM_011533287 XP_011531589 XM_011533288 XP_011531590 XM_011533289 XP_011531591 XR_940364 NM_006545 NP_006536 |
| Function | Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. {ECO:0000269|PubMed:18616680, ECO:0000269|PubMed:23723238}. |
| Tissue Specificity | Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested. |
NPRL2 CRISPR/Cas9 KO Plasmid (h) - sc-402875 from Santa Cruz Biotechnology
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NPRL2 HDR Plasmid (h) - sc-402875-HDR from Santa Cruz Biotechnology
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NPRL2 Double Nickase Plasmid (h) - sc-402875-NIC from Santa Cruz Biotechnology
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NPRL2 Double Nickase Plasmid (h2) - sc-402875-NIC-2 from Santa Cruz Biotechnology
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NPRL2 CRISPR Activation Plasmid (h) - sc-402875-ACT from Santa Cruz Biotechnology
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NPRL2 CRISPR Activation Plasmid (h2) - sc-402875-ACT-2 from Santa Cruz Biotechnology
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NPRL2 Lentiviral Activation Particles (h) - sc-402875-LAC from Santa Cruz Biotechnology
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NPRL2 Lentiviral Activation Particles (h2) - sc-402875-LAC-2 from Santa Cruz Biotechnology
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NPRL2 siRNA (h) - sc-62699 from Santa Cruz Biotechnology
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NPRL2 shRNA Plasmid (h) - sc-62699-SH from Santa Cruz Biotechnology
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NPRL2 shRNA (h) Lentiviral Particles - sc-62699-V from Santa Cruz Biotechnology
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Natriuretic Peptide Receptor B RNAi - H00004882-R07 from Novus Biologicals
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Natriuretic Peptide Receptor B RNAi - H00004882-R08 from Novus Biologicals
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MISSION® esiRNA - EHU156761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15469 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15469 from Sigma-Aldrich
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NPRL2 siRNA (Human) - CRH7251 from Cohesion Biosciences
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shRNA set against Human NPRL2 (NM_006545.4) - SHH354428 from Creative biogene
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shRNA set against Human TUSC4(NM_006545.4) - SHR018858 from Creative biogene
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Human NPRL2 siRNA - orb267753 from Biorbyt
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NPRL2 shRNA Plasmid (Human) - CHH7251 from Cohesion Biosciences
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NPRL2 miRNA 3'UTR clone - MiUTR1H-10886 from Creative biogene
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