| Gene Symbol |
NPRL2
|
| Entrez Gene |
10641
|
| Alt Symbol |
NPR2, NPR2L, TUSC4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nitrogen permease regulator-like 2 (S. cerevisiae)
|
| Other Description |
2810446G01Rik|G21 protein|NPR2-like protein|gene 21 protein|homologous to yeast nitrogen permease (candidate tumor suppressor)|nitrogen permease regulator 2-like protein|tumor suppressor candidate 4
|
| Swissprots |
Q9Y249 Q6FGS2 A8K831 Q9Y497 Q8WTW4
|
| Accessions |
AAB67310 EAW65106 EAW65107 EAW65108 EAW65109 EAW65110 EAW65111 EAW65112 Q8WTW4 AF040707 AAC62535 AF040708 AAC62536 AK098161 AK292196 BAF84885 AK309658 AL833426 BC008802 BC021984 AAH21984 BC050412 BC056861 AAH56861 BC063030 CR542035 CAG46832 XM_005264806 XP_005264863 XM_005264808 XP_005264865 XM_011533287 XP_011531589 XM_011533288 XP_011531590 XM_011533289 XP_011531591 XR_940364 NM_006545 NP_006536
|
| Function |
Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. {ECO:0000269|PubMed:18616680, ECO:0000269|PubMed:23723238}.
|
| Tissue Specificity |
Most abundant in skeletal muscle, followed by brain, liver and pancreas, with lower amounts in lung, kidney, placenta and heart. Expressed in most lung cancer cell lines tested.
|