SEPT4

Gene Symbol SEPT4
Entrez Gene 5414
Alt Symbol ARTS, BRADEION, CE5B3, H5, MART, PNUTL2, SEP4, hCDCREL-2, hucep-7
Species Human
Gene Type protein-coding
Description septin 4
Other Description CE5B3 beta|apoptosis-related protein in the TGF-beta signaling pathway|bradeion beta|brain protein H5|cell division control-related protein 2|cerebral protein 7|peanut-like protein 2|septin-4|septin-M
Swissprots O43236 B4DXV5 B3KSX9 Q9UM58 Q6IAP3 B2RD42 B4DXC6 Q9H315
Accessions CCQ43816 EAW94440 EAW94441 EAW94442 EAW94443 EAW94444 EAW94445 EAW94446 EAW94447 EAW94448 EAW94449 EAW94450 EAW94451 EAW94452 EAW94453 O43236 AB002110 BAB70694 AB008753 BAB70695 AB010642 AF035811 AAB88512 AF073312 AAC25673 AF176379 AAG45673 AK091065 BAG52275 AK094579 BAG52891 AK126631 AK294094 BAG57432 AK295527 BAG58440 AK301914 BAG63338 AK302146 BAG63517 AK308957 AK314528 BAG37122 AK315045 AK315396 BAG37789 BC018055 BC018056 AAH18056 BC128255 BC128515 BC142968 CR457111 CAG33392 D89278 BAB46922 DA076433 DA180095 DA343015 DC361494 DQ892336 ABM83262 DQ895541 ABM86467 U88829 AAD00653 U88870 AAD00657 XM_006721949 XP_006722012 XM_006721950 XP_006722013 XM_006721951 XP_006722014 XM_006721952 XP_006722015 XM_006721954 XP_006722017 XM_006721955 XP_006722018 XM_011524910 XP_011523212 XM_011524911 XP_011523213 XM_011524912 XP_011523214 NM_001198713 NP_001185642 NM_001256782 NP_001243711 NM_001256822 NP_001243751 NM_004574 NP_004565 NM_080415 NP_536340 NM_080416 NP_536341 NR_037155 NR_104196 NR_104197 NM_080417
Function Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion. Isoform ARTS, but not the other isoforms, is required for the induction of cell death mediated by TGF-beta and by other apoptotic stimuli. {ECO:0000250, ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15837787, ECO:0000269|PubMed:9889007, ECO:0000305}.
Subcellular Location Cytoplasm {ECO:0000250}. Cytoplasm, cytoskeleton {ECO:0000250}. Note=In platelets, found in areas surrounding alpha-granules. {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:15029247, ECO:0000269|PubMed:15116257}.
Tissue Specificity Widely expressed in adult and fetal tissues with highest expression in adult brain (at protein level), heart, liver and adrenal gland and fetal heart, kidney, liver and lung. Also expressed in colorectal cancers and malignant melanomas. Expressed in platelets. {ECO:0000269|PubMed:11146656, ECO:0000269|PubMed:11167005, ECO:0000269|PubMed:11511094, ECO:0000269|PubMed:15116257, ECO:0000269|PubMed:15915442, ECO:0000269|PubMed:9889007}.

Septin 4 (H-120) - sc-20179 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Septin 4 (H-120): sc-20179. Immunoperoxidase staining of formalin fixed, paraffin-embedded mouse lymph node showing cytoplasmic localization.

Septin 4 (C-16) - sc-20415 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Septin 4 (N-20) - sc-23781 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-ARTS antibody - ab9651 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of ARTS expression in human lung (lane 1), spleen (lane 2), and kidney (lane 3) tissue lysates with anti-ARTS at 2 µg /ml.

Anti-ARTS antibody - ab48579 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Human heart tissue with myocardial cells (approximately 10µg) positively stained (arrows). Antibody concentration 4-8µg/ml. Magnification: 400x

Anti-ARTS antibody - ab10441 from Abcam

Prices $370.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ARTS antibody [ARTS51] - ab10440 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Monoclonal
Clone ARTS51

Anti-SEPT4 antibody - ab172106 from Abcam

Prices $370.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-SEPT4 antibody (ab172106) at 1/500 dilutionLane 1 : SEPT4 transfected 293T lysateLane 2 : Non-transfected 293T lysate.Lysates/proteins at 15 µl per lane.SecondaryGoat Anti-Mouse IgG (H&L)-HRP at 1/2500 dilutiondeveloped using the ECL technique

Anti-SEPT4 antibody - C-terminal - ab189631 from Abcam

Host Rabbit
Clonality Polyclonal
Anti-Histone H3 (mutated K27 M) antibody (ab190631) at 1/1000 dilution + HeLa cell lysate

Anti-SEPT4 / Septin 4 Antibody (N-Terminus) IHC-plus™ - LS-B549 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-SEPT4 / Septin 4 antibody IHC of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B549 concentration 5 ug/ml.

Anti-SEPT4 / Septin 4 Antibody (aa48-59) - LS-C139661 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
SEPT4 antibody (0.5 ug/ml) staining of Human Cerebellum lysate (35 ug protein/ml in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-SEPT4 / Septin 4 Antibody (aa440-450) IHC-plus™ - LS-B8346 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-SEPT4 / Septin-4 antibody IHC of human brain, cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8346 dilution 3.75 ug/ml.

Anti-SEPT4 / Septin 4 Antibody (aa3-14) - LS-C82959 from LifeSpan Bioscience

Prices $385.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEPT4 / Septin 4 Antibody - LS-C178416 from LifeSpan Bioscience

Prices $255.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEPT4 / Septin 4 Antibody - LS-C194047 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEPT4 / Septin 4 Antibody (aa125-141) - LS-C194048 from LifeSpan Bioscience

Prices $905.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SEPT4 / Septin 4 Antibody (N-Terminus) - LS-C29924 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SEPT4 / Septin 4 antibody LS-C29924 was used in IHC to stain formalin-fixed, paraffin-embedded human heart.

Septin-4 Antibody - NBP1-90094 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: Septin-4 Antibody [NBP1-90094] - Lane 1: Marker [kDa] 230, 130, 95, 72, 56, 36, 28, 17, 11<br/>Lane 2: Human cell line RT-4<br/>Lane 3: Human cell line U-251MG sp<br/>Lane 4: Human plasma (IgG/HSA depleted)<br/>Lane 5: Human liver tissue<br/>Lane 6: Human tonsil tissue

Septin-4 Antibody - NBP1-90093 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Septin-4 Antibody - NBP1-02711 from Novus Biologicals

Prices $329.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: Septin-4 Antibody [NBP1-02711] - Staining of human lung, respiratory epithelium. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.

Septin-4 Antibody - NBP1-52096 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Septin-4 Antibody [NBP1-52096] - Western blot analysis of Septin-4 (aa33-44) in Human Cerebellum lysate (35ug protein in RIPA buffer) using NBP1-52096 at 0.5ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Septin-4 Antibody - NBP1-52095 from Novus Biologicals

Prices $299.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Western Blot: Septin-4 Antibody [NBP1-52095] - Western blot analysis of Septin-4 (aa425-435) in Human Heart lysate (35ug protein in RIPA buffer) using NBP1-52095 at 1ug/ml. Primary incubation was 1 hour. Detected by chemiluminescence.

Septin-4 Antibody - H00005414-B01 from Novus Biologicals

Prices $359.00
Sizes 50 µl
Host Mouse
Clonality Polyclonal

SEPT4 Polyclonal Antibody - bs-7096R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin embedded rat brain labeled with Rabbit Anti ARTS Polyclonal Antibody, Unconjugated (bs-7096R) at 1:200 followed by conjugation to the secondary antibody and DAB staining

Anti-SEPT4 antibody produced in rabbit - HPA021587 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-SEPT4: <B>Cat. No. HPA021587</B>: Immunohistochemical staining of human cerebellum shows moderate cytoplasmic positivity in cells in granular layer and distinctly stained neuropil.
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