| Gene Symbol |
G3BP1
|
| Entrez Gene |
10146
|
| Alt Symbol |
G3BP, HDH-VIII
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
GTPase activating protein (SH3 domain) binding protein 1
|
| Other Description |
ATP-dependent DNA helicase VIII|G3BP-1|GAP SH3 domain-binding protein 1|GAP binding protein|Ras-GTPase-activating protein SH3-domain-binding protein|RasGAP-associated endoribonuclease G3BP|ras GTPase-activating protein-binding protein 1
|
| Swissprots |
Q13283 Q5HYE9
|
| Accessions |
CAH05301 EAW61659 EAW61660 EAW61661 EAW61662 Q13283 AK091592 AK128316 AK130003 BAC85272 AK222606 BAD96326 AK300098 BAG61899 AK303580 BAH13990 AK309172 AK311635 AK312572 BAG35467 BC006997 AAH06997 BC108278 AAI08279 BG703413 BT019384 AAV38191 BU517281 BX647869 CAI46065 BX648012 CAI46067 CR536535 CAG38772 DQ893058 ABM83984 DQ896308 ABM87307 U32519 AAB07787 X78262 XM_006714749 XP_006714812 XM_006714750 XP_006714813 NM_005754 NP_005745 NM_198395 NP_938405
|
| Function |
May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:9889278}.
|
| Subcellular Location |
Cytoplasm. Cytoplasm, cytosol. Cytoplasmic granule. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous.
|
