G3BP1

Gene Symbol	G3BP1
Entrez Gene	10146
Alt Symbol	G3BP, HDH-VIII
Species	Human
Gene Type	protein-coding
Description	GTPase activating protein (SH3 domain) binding protein 1
Other Description	ATP-dependent DNA helicase VIII|G3BP-1|GAP SH3 domain-binding protein 1|GAP binding protein|Ras-GTPase-activating protein SH3-domain-binding protein|RasGAP-associated endoribonuclease G3BP|ras GTPase-activating protein-binding protein 1
Swissprots	Q13283 Q5HYE9
Accessions	CAH05301 EAW61659 EAW61660 EAW61661 EAW61662 Q13283 AK091592 AK128316 AK130003 BAC85272 AK222606 BAD96326 AK300098 BAG61899 AK303580 BAH13990 AK309172 AK311635 AK312572 BAG35467 BC006997 AAH06997 BC108278 AAI08279 BG703413 BT019384 AAV38191 BU517281 BX647869 CAI46065 BX648012 CAI46067 CR536535 CAG38772 DQ893058 ABM83984 DQ896308 ABM87307 U32519 AAB07787 X78262 XM_006714749 XP_006714812 XM_006714750 XP_006714813 NM_005754 NP_005745 NM_198395 NP_938405
Function	May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:9889278}.
Subcellular Location	Cytoplasm. Cytoplasm, cytosol. Cytoplasmic granule. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. {ECO:0000250}.
Tissue Specificity	Ubiquitous.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

G3BP1 CRISPR/Cas9 KO Plasmid (h) - sc-400745 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 HDR Plasmid (h) - sc-400745-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 Double Nickase Plasmid (h) - sc-400745-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 Double Nickase Plasmid (h2) - sc-400745-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 CRISPR Activation Plasmid (h) - sc-400745-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 CRISPR Activation Plasmid (h2) - sc-400745-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 Lentiviral Activation Particles (h) - sc-400745-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 Lentiviral Activation Particles (h2) - sc-400745-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

G3BP1 siRNA (h) - sc-75076 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

G3BP1 shRNA Plasmid (h) - sc-75076-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

G3BP1 shRNA (h) Lentiviral Particles - sc-75076-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

G3BP1 RNAi - H00010146-R01V from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

G3BP1 RNAi - H00010146-R03 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU113241 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN9032 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND9032 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR09003 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr09003

G3BP1 siRNA (Human) - CRH6846 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

G3BP1 RNAi - H00010146-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

G3BP1 - MBS8232597 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human G3BP1 (NM_005754.2) - SHH298205 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human G3BP1(NM_005754.2) - SHH072479 from Creative biogene Category siRNA Species Reactivities Human

Human G3BP1 siRNA - orb267348 from Biorbyt Category siRNA Prices $485.00, $629.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

G3BP1 shRNA Plasmid (Human) - CHH6846 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

G3BP1 miRNA 3'UTR clone - MiUTR1H-03893 from Creative biogene Species Reactivities Human

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