G3BP1

Gene Symbol	G3BP1
Entrez Gene	10146
Alt Symbol	G3BP, HDH-VIII
Species	Human
Gene Type	protein-coding
Description	GTPase activating protein (SH3 domain) binding protein 1
Other Description	ATP-dependent DNA helicase VIII|G3BP-1|GAP SH3 domain-binding protein 1|GAP binding protein|Ras-GTPase-activating protein SH3-domain-binding protein|RasGAP-associated endoribonuclease G3BP|ras GTPase-activating protein-binding protein 1
Swissprots	Q13283 Q5HYE9
Accessions	CAH05301 EAW61659 EAW61660 EAW61661 EAW61662 Q13283 AK091592 AK128316 AK130003 BAC85272 AK222606 BAD96326 AK300098 BAG61899 AK303580 BAH13990 AK309172 AK311635 AK312572 BAG35467 BC006997 AAH06997 BC108278 AAI08279 BG703413 BT019384 AAV38191 BU517281 BX647869 CAI46065 BX648012 CAI46067 CR536535 CAG38772 DQ893058 ABM83984 DQ896308 ABM87307 U32519 AAB07787 X78262 XM_006714749 XP_006714812 XM_006714750 XP_006714813 NM_005754 NP_005745 NM_198395 NP_938405
Function	May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium- dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA. {ECO:0000269|PubMed:11604510, ECO:0000269|PubMed:9889278}.
Subcellular Location	Cytoplasm. Cytoplasm, cytosol. Cytoplasmic granule. Cell membrane. Nucleus. Note=Cytoplasmic in proliferating cells, can be recruited to the plasma membrane in exponentially growing cells (By similarity). Cytosolic and partially nuclear in resting cells. Recruited to stress granules (SGs) upon either arsenite or high temperature treatment. Recruitment to SGs is influenced by HRAS. {ECO:0000250}.
Tissue Specificity	Ubiquitous.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human G3BP full length protein - ab103304 from Abcam Category Protein Source E. coli Species Human

G3BP1 / G3BP Antibody Blocking Peptide - LS-E2706 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

G3BP1 / G3BP Antibody Blocking Peptide - LS-E13524 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

G3BP1 / G3BP Antibody Blocking Peptide - LS-E13523 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human G3BP1 Protein - NBP1-50925 from Novus Biologicals Category Protein Prices $349.00 Sizes 50 µg Source E.coli Species Human

Recombinant Human G3BP1 Protein - H00010146-Q01 from Novus Biologicals Category Protein Prices $529.00 Sizes 25 µg Source Wheat Germ Species Human

Recombinant Human G3BP1 Protein - H00010146-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

G3BP1-Antibody-C-term-Blocking-peptide - BP13785b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

G3BP1 Protein (OPPA02533) - OPPA02533 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source E. Coli

Human G3BP1 protein - orb168373 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

G3BP Blocking Peptide - 33R-2785 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

G3BP1 Blocking Peptide - 33R-7905 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

G3BP1 protein (His tag) - 80R-1601 from Fitzgerald Category Protein Prices $340.00 Sizes 50 µg Source E.coli

G3BP1 (phospho-Ser232) Blocking Peptide - abx063650 from Abbexa Category Peptide Species Human

G3BP1 Blocking Peptide - abx063651 from Abbexa Category Peptide Species Human, Mouse, Rat

G3BP1 / G3BP (1-466, His-tag) - AR09781PU-L from Acris Antibodies Category Protein Prices $1,010.00 Sizes 250 µg Source E. coli Species Human

G3BP1 / G3BP (1-466, His-tag) - AR09781PU-N from Acris Antibodies Category Protein Prices $410.00 Sizes 50 µg Source E. coli Species Human

G3BP1 / G3BP - H00010146-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

G3BP1 / G3BP - H00010146-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

G3BP1 / G3BP - H00010146-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

G3BP1 / G3BP - H00010146-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GTPase Activating Protein (SH3 domain) Binding Protein 1, Human Recombinant - 228-12200-1 from RayBiotech Category Protein Prices $118.00 Sizes 1 µg Source Escherichia Coli. Species Human

G3BP1, 1-466aa, Human, His tag, E.coli - 01-P0841 from ARP American Research Products Category Protein Prices $179.00, $449.00, $1,089.00 Sizes 10 µg, 50 µg, 250 µg Species Human

G3BP1 fusion protein - Ag3728 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

G3BP1 Human - ENPS-055 from NeoScientific Category Protein Prices $65.00, $169.00, $6,760.00 Sizes 2 µg, 10 µg, 1 mg Source Escherichia Coli. Species Human

Search more