| Gene Symbol |
ALCAM
|
| Entrez Gene |
214
|
| Alt Symbol |
CD166, MEMD
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
activated leukocyte cell adhesion molecule
|
| Other Description |
CD166 antigen
|
| Swissprots |
Q1HGM9 B2RNS3 B4DTU0 Q1HGM8 Q13740 Q6PEY4 Q6ZS95 O60892
|
| Accessions |
EAW79755 EAW79756 EAW79757 Q13740 AB074167 AK054632 BAG51401 AK095833 AK127617 BAC87059 AK300362 BAG62102 AK301804 BAG63255 AK316113 BAH14484 AL833702 AY644765 AAV28819 BC029639 BC041127 BC057809 AAH57809 BC137096 AAI37097 BC137097 AAI37098 CA430528 CB145726 DA318514 DB541501 DQ486139 ABF48405 DQ486140 ABF48406 L38608 AAB59499 Y10183 CAA71256 NM_001243280 NP_001230209 NM_001243281 NP_001230210 NM_001243283 NP_001230212 NM_001627 NP_001618
|
| Function |
Cell adhesion molecule that binds to CD6. Involved in neurite extension by neurons via heterophilic and homophilic interactions. May play a role in the binding of T- and B-cells to activated leukocytes, as well as in interactions between cells of the nervous system.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Spleen, placenta, liver, and weakly in liver. Expressed by activated T-cells, B-cells, monocytes and thymic epithelial cells. Expressed by neurons in the brain. Restricted expression in tumor cell lines. Preferentially expressed in highly metastasizing melanoma cell lines. {ECO:0000269|PubMed:9502422}.
|
| Top Pathways |
Cell adhesion molecules (CAMs)
|