| Gene Symbol | RRP8 |
|---|---|
| Entrez Gene | 23378 |
| Alt Symbol | KIAA0409, NML |
| Species | Human |
| Gene Type | protein-coding |
| Description | ribosomal RNA processing 8, methyltransferase, homolog (yeast) |
| Other Description | RRP8 methyltransferase homolog|cerebral protein 1|nucleomethylin|ribosomal RNA-processing protein 8 |
| Swissprots | O43159 Q7KZ78 Q9BVM6 |
| Accessions | EAW68691 O43159 AB007869 BAA23705 BC001071 AAH01071 BX417992 D87060 BAB46916 JF432519 ADZ15736 R51624 XM_011519955 XP_011518257 XR_930858 XR_930859 XR_930860 NM_015324 NP_056139 |
| Function | Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}. |
| Subcellular Location | Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus. |