RRP8

Gene Symbol RRP8
Entrez Gene 23378
Alt Symbol KIAA0409, NML
Species Human
Gene Type protein-coding
Description ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Other Description RRP8 methyltransferase homolog|cerebral protein 1|nucleomethylin|ribosomal RNA-processing protein 8
Swissprots O43159 Q7KZ78 Q9BVM6
Accessions EAW68691 O43159 AB007869 BAA23705 BC001071 AAH01071 BX417992 D87060 BAB46916 JF432519 ADZ15736 R51624 XM_011519955 XP_011518257 XR_930858 XR_930859 XR_930860 NM_015324 NP_056139
Function Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}.
Subcellular Location Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus.

RRP8 CRISPR/Cas9 KO Plasmid (h) - sc-411727 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 HDR Plasmid (h) - sc-411727-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 Double Nickase Plasmid (h) - sc-411727-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 Double Nickase Plasmid (h2) - sc-411727-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 CRISPR Activation Plasmid (h) - sc-411727-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 CRISPR Activation Plasmid (h2) - sc-411727-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 Lentiviral Activation Particles (h) - sc-411727-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 Lentiviral Activation Particles (h2) - sc-411727-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

RRP8 siRNA (h) - sc-97009 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RRP8 shRNA Plasmid (h) - sc-97009-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

RRP8 shRNA (h) Lentiviral Particles - sc-97009-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU010111 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18699 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18699 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RRP8 siRNA (Human) - CRH8222 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RRP8 - MBS8202896 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human RRP8 (NM_015324.3) - SHH400084 from Creative biogene

Category siRNA
Species Reactivities Human

Human RRP8 siRNA - orb268724 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RRP8 shRNA Plasmid (Human) - CHH8222 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RRP8 miRNA 3'UTR clone - MiUTR3H-15968 from Creative biogene

Species Reactivities Human
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