RRP8

Gene Symbol	RRP8
Entrez Gene	23378
Alt Symbol	KIAA0409, NML
Species	Human
Gene Type	protein-coding
Description	ribosomal RNA processing 8, methyltransferase, homolog (yeast)
Other Description	RRP8 methyltransferase homolog|cerebral protein 1|nucleomethylin|ribosomal RNA-processing protein 8
Swissprots	O43159 Q7KZ78 Q9BVM6
Accessions	EAW68691 O43159 AB007869 BAA23705 BC001071 AAH01071 BX417992 D87060 BAB46916 JF432519 ADZ15736 R51624 XM_011519955 XP_011518257 XR_930858 XR_930859 XR_930860 NM_015324 NP_056139
Function	Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys- 9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase. Its substrates are however unknown. {ECO:0000269|PubMed:18485871}.
Subcellular Location	Nucleus, nucleolus {ECO:0000269|PubMed:11790298, ECO:0000269|PubMed:12429849, ECO:0000269|PubMed:18485871}. Note=Localizes at rDNA locus.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human HUCE1 full length protein - ab161616 from Abcam Category Protein Source Wheat germ Species Human

RRP8 Antibody Blocking Peptide - LS-E24593 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

RRP8 Antibody Blocking Peptide - LS-E24592 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human HUCE1 Protein - H00023378-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

RRP8 - H00023378-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

RRP8 - H00023378-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

RRP8 fusion protein - ag16803 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

RRP8 fusion protein - ag13994 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Cerebral 1 (L310) Peptide - BS3101P from Bioworld Technology Category Peptide Prices $158.00 Sizes 100 µl

Recombinant Human Ribosomal RNA-processing protein 8(RRP8) - CSB-YP020531HU CSB-EP020531HU CSB-BP020531HU CSB-MP020531HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

RRP8 - TP300844 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

HUCE1 Recombinant Protein Antigen - NBP1-89618PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

RRP8 Blocking Peptide - abx061288 from Abbexa Category Peptide Species Human

RRP8 Peptide, Human - M34GP13636H from Creative Peptides Category Peptide Source Synthetic. Species Human

RRP8 Blocking Peptide - CBP5201 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

Ribosomal RNA-processing protein 8 (RRP8), Recombinant Protein - MBS1183304 from MyBioSource Category Protein Prices $1,235.00, $1,235.00, $1,455.00, $1,455.00, $2,010.00, $2,010.00, $2,475.00, $2,475.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

HUCE1 Recombinant Protein Antigen - NBP2-55730PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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