| Gene Symbol |
TNPO1
|
| Entrez Gene |
3842
|
| Alt Symbol |
IPO2, KPNB2, MIP, MIP1, TRN
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
transportin 1
|
| Other Description |
M9 region interaction protein|importin 2|importin beta 2|importin beta-2|karyopherin (importin) beta 2|karyopherin beta-2|transportin-1
|
| Swissprots |
B4DVC6 Q92975 Q92973 Q92957
|
| Accessions |
EAW95713 EAW95714 EAW95715 Q92973 AK055669 AK124768 AK299671 BAG61582 AK301021 BAG62638 AK308177 BC040340 AAH40340 EU176628 ABW03429 U70322 AAC50723 U72069 AAB58254 U72395 AAB68948 XM_005248500 XP_005248557 XM_005248501 XP_005248558 XR_948249 NM_002270 NP_002261 NM_153188 NP_694858
|
| Function |
Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involv
|
| Subcellular Location |
Cytoplasm. Nucleus.
|