TNPO1
| Gene Symbol | TNPO1 |
|---|---|
| Entrez Gene | 3842 |
| Alt Symbol | IPO2, KPNB2, MIP, MIP1, TRN |
| Species | Human |
| Gene Type | protein-coding |
| Description | transportin 1 |
| Other Description | M9 region interaction protein|importin 2|importin beta 2|importin beta-2|karyopherin (importin) beta 2|karyopherin beta-2|transportin-1 |
| Swissprots | B4DVC6 Q92975 Q92973 Q92957 |
| Accessions | EAW95713 EAW95714 EAW95715 Q92973 AK055669 AK124768 AK299671 BAG61582 AK301021 BAG62638 AK308177 BC040340 AAH40340 EU176628 ABW03429 U70322 AAC50723 U72069 AAB58254 U72395 AAB68948 XM_005248500 XP_005248557 XM_005248501 XP_005248558 XR_948249 NM_002270 NP_002261 NM_153188 NP_694858 |
| Function | Functions in nuclear protein import as nuclear transport receptor. Serves as receptor for nuclear localization signals (NLS) in cargo substrates. Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (By similarity). Involved in nuclear import of M9- containing proteins. In vitro, binds directly to the M9 region of the heterogeneous nuclear ribonucleoproteins (hnRNP), A1 and A2 and mediates their nuclear import. Appears also to be involv |
| Subcellular Location | Cytoplasm. Nucleus. |
karyopherin β2 siRNA (h) - sc-35737 from Santa Cruz Biotechnology
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karyopherin β2 shRNA Plasmid (h) - sc-35737-SH from Santa Cruz Biotechnology
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karyopherin β2 shRNA (h) Lentiviral Particles - sc-35737-V from Santa Cruz Biotechnology
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Transportin 1 RNAi - H00003842-R02 from Novus Biologicals
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Transportin 1 RNAi - H00003842-R01 from Novus Biologicals
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MISSION® esiRNA - EHU113141 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21793 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21793 from Sigma-Aldrich
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TNPO1 siRNA (Human) - CRH2605 from Cohesion Biosciences
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TNPO1 - MBS828762 from MyBioSource
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shRNA set against Human TNPO1 (NM_002270.3) - SHH432476 from Creative biogene
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shRNA set against Human TNPO1(NM_002270.3) - SHL043194 from Creative biogene
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shRNA set against Human TNPO1(NM_153188.2) - SHL043212 from Creative biogene
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Human TNPO1 siRNA - orb263107 from Biorbyt
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TNPO1 shRNA Plasmid (Human) - CHH2605 from Cohesion Biosciences
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TNPO1 miRNA 3'UTR clone - MiUTR1H-10626 from Creative biogene
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TNPO1 miRNA 3'UTR clone - MiUTR1H-10627 from Creative biogene
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