| Gene Symbol |
PARD6B
|
| Entrez Gene |
84612
|
| Alt Symbol |
PAR6B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
par-6 family cell polarity regulator beta
|
| Other Description |
PAR-6 beta|par-6 partitioning defective 6 homolog beta|partitioning defective 6 homolog beta
|
| Swissprots |
Q9BYG5 Q9Y510 A2A2A7
|
| Accessions |
EAW75615 EAW75616 EAW75617 Q9BYG5 AB044555 BAB40756 AB178534 BAF92013 BC060847 AAH60847 CA435324 HQ448524 ADQ33003 NM_032521 NP_115910
|
| Function |
Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins.
|
| Subcellular Location |
Cytoplasm. Cell membrane {ECO:0000250}. Cell junction, tight junction {ECO:0000250}.
|
| Tissue Specificity |
Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues.
|
| Top Pathways |
Tight junction, Endocytosis, Hippo signaling pathway, Rap1 signaling pathway
|