| Gene Symbol |
SIGLEC11
|
| Entrez Gene |
114132
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
sialic acid binding Ig-like lectin 11
|
| Other Description |
sialic acid-binding Ig-like lectin 11|siglec-11
|
| Swissprots |
Q96RL6
|
| Accessions |
EAW52584 EAW52585 EAW52586 EAW52587 Q96RL6 AB072038 BAB86816 AF337818 AAK72907 AY358135 AAQ88502 BC156822 AAI56823 XM_005258476 XP_005258533 XM_005258477 XP_005258534 XR_243888 NM_001135163 NP_001128635 NM_052884 NP_443116
|
| Function |
Putative adhesion molecule that mediates sialic-acid dependent binding to cells. Preferentially binds to alpha-2,8- linked sialic acid. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In the immune response, may act as an inhibitory receptor upon ligand induced tyrosine phosphorylation by recruiting cytoplasmic phosphatase(s) via their SH2 domain(s) that block signal transduction through dephosphorylation of signaling molecules.
|
| Subcellular Location |
Membrane; Single-pass type I membrane protein.
|
| Tissue Specificity |
Expressed by macrophages in various tissues including Kupffer cells. Also found in brain microglia.
|
![Western Blot: SIGLEC11 Overexpression Lysate (Adult Normal) [NBL1-15958] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SIGLEC11.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8068_SIGLEC11%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-15958-img0002.jpg)