FLT4

Gene Symbol FLT4
Entrez Gene 2324
Alt Symbol FLT41, LMPH1A, PCL, VEGFR3
Species Human
Gene Type protein-coding
Description fms-related tyrosine kinase 4
Other Description FLT-4|VEGFR-3|fms-like tyrosine kinase 4|soluble VEGFR3 variant 1|soluble VEGFR3 variant 2|soluble VEGFR3 variant 3|tyrosine-protein kinase receptor FLT4|vascular endothelial growth factor receptor 3
Swissprots Q86W07 A8K6L4 P35916 Q86W08 Q16067 B5A926
Accessions AAB23636 AFN73242 AFN73243 AFN73244 AIU34641 AIU34642 AIY55328 AIY55329 AIY55330 AIY55331 AIY55332 AIY55333 AIY55334 AIY55335 AIY55336 AIY55337 AIY55338 AIY55339 AIY55340 CAI84582 CAJ32888 CAJ32905 CAJ33671 CAJ33685 CBH30507 CBH30547 EAW53749 EAW53750 P35916 AB209637 BAD92874 AK291679 BAF84368 AK309910 AY233382 AAO89504 AY233383 AAO89505 BC027302 BC167816 AAI67816 CA438330 DB455035 EU826564 ACF47600 EU826565 ACF47601 EU826566 ACF47602 S66407 AAB28539 U43143 AAA85215 X68203 CAA48290 X69878 CAA49505 XM_011534477 XP_011532779 XM_011534478 XP_011532780 XM_011534479 XP_011532781 XM_011534480 XP_011532782 XM_011534481 XP_011532783 XM_011534482 XP_011532784 XM_011534483 XP_011532785 XM_011534484 XP_011532786 XR_941095 NM_002020 NP_002011 NM_182925 NP_891555
Function Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph
Subcellular Location Isoform 2: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. {ECO:0000269|PubMed:1327515, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:7675451}.
Top Pathways Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway

VEGF Receptor 3 (C28G5) Rabbit mAb - 2638 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C28G5
Western blot analysis of extracts from COS cells transfected with human VEGFR3 expression constructs (right) and mock transfected COS cells (left) using VEGF Receptor 3 (C28G5) Rabbit mAb.

VEGF Receptor 3 (C82A2) Rabbit mAb - 3408 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C82A2
Western blot analysis of extracts from COS cells, untreated or transfected with human VEGFR3, using VEGF Receptor 3 (C82A2) Rabbit mAb.

VEGF Receptor 3 Antibody - 2485 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of cell lysates from COS cells, either untransfected or overexpressing VEGFR-3, using VEGF Receptor 3 Antibody.

Flt-4 (G-3) - sc-365748 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Flt-4 (G-3): sc-365748. Western blot analysis of Flt-4 expression in HEL 92.1.7 whole cell lysate.

Flt-4 (C-20) - sc-321 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Flt-4 expression in K-562 whole cell lysate (A) and rat liver extract (B). Antibodies tested include Flt-4 (C-20): sc-321 (A) and Flt-4 (M-20): sc-637 (B).

Flt-4 (D-6) - sc-28297 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Flt-4 (D-6): sc-28297. Western blot analysis of human recombinant Flt-4.

Flt-4 (H-240) - sc-20734 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Flt-4 (H-240): sc-20734. Western blot analysis of Flt-4 expression in K-562 whole cell lysate.

Flt-4 (M-20) - sc-637 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Western blot analysis of Flt-4 expression in K-562 whole cell lysate (A) and rat liver extract (B). Antibodies tested include Flt-4 (C-20): sc-321 (A) and Flt-4 (M-20): sc-637 (B).

Anti-VEGF Receptor 3 antibody - ab27278 from Abcam

Prices $398.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Ab27278 at a dilution of 1/100, staining formalin fixed paraffin embedded Flt4 in human placenta by Immunohistochemistry.

Anti-VEGF Receptor 3 antibody - ab10284 from Abcam

Prices $387.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Immunohistochemistry (Frozen sections) analysis of human spleen tissue labelling VEGF Receptor 3 with ab10284.

Anti-VEGF Receptor 3 antibody - ab89501 from Abcam

Prices $376.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Anti-VEGF Receptor 3 antibody (ab89501) at 5 µg/ml + Partial tagged recombinant Human VEGF Receptor 3 protein at 0.2 µg

Anti-VEGF Receptor 3 antibody - ab154079 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Anti-VEGF Receptor 3 antibody (ab154079) at 1/1000 dilution + MOLT4 whole cell lysate at 30 µg

Anti-VEGF Receptor 3 antibody [44CT92.4.4] - ab72240 from Abcam

Prices $379.00
Sizes 400 µl
Host Mouse
Clonality Monoclonal
Clone 44CT92.4.4
Anti-VEGF Receptor 3 antibody [44CT92.4.4] (ab72240) at 1/2000 dilution + VGFR3 recombinant fragment

Anti-VEGF Receptor 3 antibody [MM0003-7G63] - ab51496 from Abcam

Prices $379.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone MM0003-7G63
ab51496 at 1/200 dilution staining VEGF Receptor 3 in human placenta tissue section by Immunohistochemistry (Formalin/ PFA fixed paraffin-embedded sections).

Anti-VEGF Receptor 3 antibody, prediluted - ab15295 from Abcam

Prices $378.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
ab15295 staining VEGF Receptor in human placenta by Immunohistochemistry (FFPE-sections).

Anti-FLT4 / VEGFR3 Antibody (C-Terminus) - LS-C6866 from LifeSpan Bioscience

Prices $475.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-FLT4 / VEGFR3 Antibody (N-Terminus) - LS-C10995 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLT4 / VEGFR3 Antibody (C-Terminus) - LS-C18484 from LifeSpan Bioscience

Prices $485.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-FLT4 / VEGFR3 Antibody (Gly990) - LS-C76798 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-FLT4 / VEGFR3 Antibody (C-Terminus) - LS-C66203 from LifeSpan Bioscience

Prices $530.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal

Anti-FLT4 / VEGFR3 Antibody (C-Terminus) - LS-C95965 from LifeSpan Bioscience

Prices $380.00, $595.00
Sizes 500 µl, 1 ml
Host Rabbit
Clonality Polyclonal

Anti-FLT4 / VEGFR3 Antibody (C-Terminus) - LS-C50652 from LifeSpan Bioscience

Prices $440.00
Sizes 250 µl
Host Rabbit
Clonality Polyclonal
Human placenta stained with Anti-Flt-4 antibody

Anti-FLT4 / VEGFR3 Antibody - LS-C132869 from LifeSpan Bioscience

Prices $445.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-FLT4 / VEGFR3 Antibody (APC) - LS-C132870 from LifeSpan Bioscience

Prices $605.00
Sizes 100 tst
Host Goat
Clonality Polyclonal

Anti-FLT4 / VEGFR3 Antibody (C-Terminus) - LS-C124784 from LifeSpan Bioscience

Prices $560.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
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