FLT4

Gene Symbol	FLT4
Entrez Gene	2324
Alt Symbol	FLT41, LMPH1A, PCL, VEGFR3
Species	Human
Gene Type	protein-coding
Description	fms-related tyrosine kinase 4
Other Description	FLT-4|VEGFR-3|fms-like tyrosine kinase 4|soluble VEGFR3 variant 1|soluble VEGFR3 variant 2|soluble VEGFR3 variant 3|tyrosine-protein kinase receptor FLT4|vascular endothelial growth factor receptor 3
Swissprots	Q86W07 A8K6L4 P35916 Q86W08 Q16067 B5A926
Accessions	AAB23636 AFN73242 AFN73243 AFN73244 AIU34641 AIU34642 AIY55328 AIY55329 AIY55330 AIY55331 AIY55332 AIY55333 AIY55334 AIY55335 AIY55336 AIY55337 AIY55338 AIY55339 AIY55340 CAI84582 CAJ32888 CAJ32905 CAJ33671 CAJ33685 CBH30507 CBH30547 EAW53749 EAW53750 P35916 AB209637 BAD92874 AK291679 BAF84368 AK309910 AY233382 AAO89504 AY233383 AAO89505 BC027302 BC167816 AAI67816 CA438330 DB455035 EU826564 ACF47600 EU826565 ACF47601 EU826566 ACF47602 S66407 AAB28539 U43143 AAA85215 X68203 CAA48290 X69878 CAA49505 XM_011534477 XP_011532779 XM_011534478 XP_011532780 XM_011534479 XP_011532781 XM_011534480 XP_011532782 XM_011534481 XP_011532783 XM_011534482 XP_011532784 XM_011534483 XP_011532785 XM_011534484 XP_011532786 XR_941095 NM_002020 NP_002011 NM_182925 NP_891555
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph
Subcellular Location	Isoform 2: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. {ECO:0000269|PubMed:1327515, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:7675451}.
Top Pathways	Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

HTScan® VEGF Receptor 3 Kinase Assay Kit - 7791 from Cell Signaling Technology Category Assay Kit

VEGF Receptor 3 Human ELISA Kit - ab100666 from Abcam Category ELISA Kit Prices $499.00 Sizes 1 x 96 tests Sensitivity < 15 pg/ml Range 12.29 pg/ml - 3000 pg/ml

Human FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F5063 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.124 ng/ml Range 12.29-1200 pg/ml

Rat FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F6803 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.064 ng/ml Range 12.29-1200 pg/ml

Human FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F213 from LifeSpan Bioscience Category ELISA Kit Prices $460.00, $840.00, $1,960.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 12.29 pg/ml Range 12.29-1200 pg/ml

Human FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F654 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 12.29-1200 pg/ml

Rat FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F10507 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 12.29-1200 pg/ml

Human FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F12947 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 12.29-1200 pg/ml

Rat FLT4 / VEGFR3 ELISA Kit (Sandwich ELISA) - LS-F12948 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.156 Range 12.29-1200 pg/ml

Phosphotyrosine FLT4 / Vascular Endothelial Growth Factor Receptor 3 ELISA Kit - RAB1009 from Sigma-Aldrich Category ELISA Kit Prices $637.00 Sizes 1 kt

Human VEGF R3 ELISA Kit - RAB0195 from Sigma-Aldrich Category ELISA Kit

Human sVEGF R3/Flt-4 DuoSet ELISA - DY349 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 156.00 - 10,000 pg/mL

Human Phospho-VEGF R3/Flt-4 DuoSet IC ELISA - DYC2724-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates)

Human Phospho-VEGF R3/Flt-4 DuoSet IC, 5 Plate - DYC2724-5 from R&D Systems Category ELISA Kit

Human Total VEGF R3/Flt-4 DuoSet IC ELISA - DYC3491-2 from R&D Systems Category ELISA Kit Prices $329.00, $649.00 Sizes 1 kit (for 2 Plates), 1 kit (for 5 Plates) Range 156.00 - 10,000 pg/mL

Human Total VEGF R3/Flt-4 DuoSet IC, 5 Plate - DYC3491-5 from R&D Systems Category ELISA Kit

Mouse VEGF R3/Flt-4 DuoSet ELISA - DY743 from R&D Systems Category ELISA Kit Prices $649.00 Sizes 1 kit (for 15 Plates) Range 62.50 - 4,000 pg/mL

Human VEGFR3 ELISA kit - 55R-27779 from Fitzgerald Category ELISA Kit Prices $645.00 Sizes 96 wells

VEGF-R3 ELISA Kit (Human) : 96 Wells (OKAG00161) - OKAG00161 from Aviva Systems Biology Category ELISA Kit Prices $390.00 Sizes 96 wells Sensitivity 157 pg/mL Range 157-1,0000 pg/mL

Vascuar endothelial cell growth factor receptor 3, VEGFR-3/Flt-4, Human, ELISA Kit - CSB-E04765h from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t Sensitivity 0.078 ng/ml Range 0.312 ng/ml-20 ng/ml

Vascular Endothelial Growth Factor Receptor 3 (VEGFR3), Human, ELISA Kit - SEB893Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.125ng/mL Range 0.312-20ng/mL

Vascular endothelial growth factor receptor 3, FLT4, Human, ELISA Kit - E0149h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t Range 0.312-20 ng/mL

Vascuoar Endothelial Cell Growth Factor Receptor 3, VEGFR-3/Flt-4, Human, ELISA Kit - YHB3186Hu from ARP American Research Products Category ELISA Kit

VEGF-R3, Human, ELISA Kit - BEK1234 from ARP American Research Products Category ELISA Kit Prices $539.00 Sizes 96 t Sensitivity < 10 pg/ml Range 30 pg/ml-850 pg/ml

VEGFR-3/Flt-4, Human, ELISA Kit - 27779 from ARP American Research Products Category ELISA Kit Prices $733.00 Sizes 96 t Range 0.03 - 2 ng/mL

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