FLT4
| Gene Symbol | FLT4 |
|---|---|
| Entrez Gene | 2324 |
| Alt Symbol | FLT41, LMPH1A, PCL, VEGFR3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | fms-related tyrosine kinase 4 |
| Other Description | FLT-4|VEGFR-3|fms-like tyrosine kinase 4|soluble VEGFR3 variant 1|soluble VEGFR3 variant 2|soluble VEGFR3 variant 3|tyrosine-protein kinase receptor FLT4|vascular endothelial growth factor receptor 3 |
| Swissprots | Q86W07 A8K6L4 P35916 Q86W08 Q16067 B5A926 |
| Accessions | AAB23636 AFN73242 AFN73243 AFN73244 AIU34641 AIU34642 AIY55328 AIY55329 AIY55330 AIY55331 AIY55332 AIY55333 AIY55334 AIY55335 AIY55336 AIY55337 AIY55338 AIY55339 AIY55340 CAI84582 CAJ32888 CAJ32905 CAJ33671 CAJ33685 CBH30507 CBH30547 EAW53749 EAW53750 P35916 AB209637 BAD92874 AK291679 BAF84368 AK309910 AY233382 AAO89504 AY233383 AAO89505 BC027302 BC167816 AAI67816 CA438330 DB455035 EU826564 ACF47600 EU826565 ACF47601 EU826566 ACF47602 S66407 AAB28539 U43143 AAA85215 X68203 CAA48290 X69878 CAA49505 XM_011534477 XP_011532779 XM_011534478 XP_011532780 XM_011534479 XP_011532781 XM_011534480 XP_011532782 XM_011534481 XP_011532783 XM_011534482 XP_011532784 XM_011534483 XP_011532785 XM_011534484 XP_011532786 XR_941095 NM_002020 NP_002011 NM_182925 NP_891555 |
| Function | Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph |
| Subcellular Location | Isoform 2: Cell membrane; Single-pass type I membrane protein. |
| Tissue Specificity | Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. {ECO:0000269|PubMed:1327515, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:7675451}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway |
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