FLT4

Gene Symbol	FLT4
Entrez Gene	2324
Alt Symbol	FLT41, LMPH1A, PCL, VEGFR3
Species	Human
Gene Type	protein-coding
Description	fms-related tyrosine kinase 4
Other Description	FLT-4|VEGFR-3|fms-like tyrosine kinase 4|soluble VEGFR3 variant 1|soluble VEGFR3 variant 2|soluble VEGFR3 variant 3|tyrosine-protein kinase receptor FLT4|vascular endothelial growth factor receptor 3
Swissprots	Q86W07 A8K6L4 P35916 Q86W08 Q16067 B5A926
Accessions	AAB23636 AFN73242 AFN73243 AFN73244 AIU34641 AIU34642 AIY55328 AIY55329 AIY55330 AIY55331 AIY55332 AIY55333 AIY55334 AIY55335 AIY55336 AIY55337 AIY55338 AIY55339 AIY55340 CAI84582 CAJ32888 CAJ32905 CAJ33671 CAJ33685 CBH30507 CBH30547 EAW53749 EAW53750 P35916 AB209637 BAD92874 AK291679 BAF84368 AK309910 AY233382 AAO89504 AY233383 AAO89505 BC027302 BC167816 AAI67816 CA438330 DB455035 EU826564 ACF47600 EU826565 ACF47601 EU826566 ACF47602 S66407 AAB28539 U43143 AAA85215 X68203 CAA48290 X69878 CAA49505 XM_011534477 XP_011532779 XM_011534478 XP_011532780 XM_011534479 XP_011532781 XM_011534480 XP_011532782 XM_011534481 XP_011532783 XM_011534482 XP_011532784 XM_011534483 XP_011532785 XM_011534484 XP_011532786 XR_941095 NM_002020 NP_002011 NM_182925 NP_891555
Function	Tyrosine-protein kinase that acts as a cell-surface receptor for VEGFC and VEGFD, and plays an essential role in adult lymphangiogenesis and in the development of the vascular network and the cardiovascular system during embryonic development. Promotes proliferation, survival and migration of endothelial cells, and regulates angiogenic sprouting. Signaling by activated FLT4 leads to enhanced production of VEGFC, and to a lesser degree VEGFA, thereby creating a positive feedback loop that enhances FLT4 signaling. Modulates KDR signaling by forming heterodimers. The secreted isoform 3 may function as a decoy receptor for VEGFC and/or VEGFD and play an important role as a negative regulator of VEGFC-mediated lymphangiogenesis and angiogenesis. Binding of vascular growth factors to isoform 1 or isoform 2 leads to the activation of several signaling cascades; isoform 2 seems to be less efficient in signal transduction, because it has a truncated C-terminus and therefore lacks several phosph
Subcellular Location	Isoform 2: Cell membrane; Single-pass type I membrane protein.
Tissue Specificity	Detected in endothelial cells (at protein level). Widely expressed. Detected in fetal spleen, lung and brain. Detected in adult liver, muscle, thymus, placenta, lung, testis, ovary, prostate, heart, and kidney. {ECO:0000269|PubMed:1327515, ECO:0000269|PubMed:20224550, ECO:0000269|PubMed:7675451}.
Top Pathways	Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human Flt4 protein fragment - ab126923 from Abcam Category Protein Prices $239.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Active human VEGF Receptor 3 protein fragment - ab95247 from Abcam Category Protein Prices $488.00 Sizes 10 µg Source Baculovirus Species Human

Active human VEGF Receptor 3 protein fragment - ab73644 from Abcam Category Protein Prices $200.00 Sizes 10 µg Source Insect cells Species Human

Human VEGF Receptor 3 full length protein - ab54261 from Abcam Category Protein Source Baculovirus Species Human

Human VEGF Receptor 3 protein fragment - ab158454 from Abcam Category Protein Source Wheat germ Species Human

Human VEGF Receptor 3 protein fragment - ab54260 from Abcam Category Protein Source Insect cells Species Human

VEGF R3/Flt-4 Partial Recombinant Protein - H00002324-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

VEGF R3/Flt-4 Recombinant Protein - P4794 from Novus Biologicals Category Protein Prices $1,559.00 Sizes 100 µg Species Human

Recombinant Human VEGF R3/Flt-4 Protein - NBP1-99430 from Novus Biologicals Category Protein Prices $190.00 Sizes 10 µg Source Insect cells Species Human

VEGF R3/Flt-4 Protein - NBP2-12566 from Novus Biologicals Category Protein Species Human

Recombinant Human VEGF R3/Flt-4 Fc Chimera, CF - 349-F4-050 from R&D Systems Category Protein Source Mouse myeloma cell line, NS0-derived

FLT4 Protein (OPPA01157) - OPPA01157 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Insect Cells

FLT4 Fc Protein (OPPA01158) - OPPA01158 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 2 µg Source Insect Cells

Human VEGFR3 Fc tag protein - orb83282 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 50 μg, 100 μg Source Human Species Human

Human FLT4 protein - orb80815 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 2 μg, 10 μg Species Human

Human VEGFR3 His tag protein - orb83152 from Biorbyt Category Protein Prices $400.00, $612.00 Sizes 50 μg, 100 μg Source Human Species Human

VEGFR-3 peptide - orb73340 from Biorbyt Category Peptide Prices $238.00 Sizes 500 µg

FLT4 protein - 30R-2790 from Fitzgerald Category Protein Prices $245.00 Sizes 10 µg Source Sf-9 insect cells Species Human

VEGFR3 protein - 30R-AV012 from Fitzgerald Category Protein Prices $525.00 Sizes 50 µg Source Sf-9 insect cells

VEGFR3 protein (Fc Chimera) - 30R-AF034 from Fitzgerald Category Protein Prices $395.00 Sizes 50 µg Source Sf-9 insect cells

VEGFR-3 / Flt-4 (His-tagged) - DA3535 from Acris Antibodies Category Protein Prices $205.00 Sizes 10 µg Source Insect cells Species Human

VEGFR-3 / Flt-4 (His-tagged) - DA3535S from Acris Antibodies Category Protein Prices $155.00 Sizes 5 µg Source Insect cells Species Human

VEGFR-3 / Flt-4 (His-tag) - DA3535X from Acris Antibodies Category Protein Prices $390.00 Sizes 50 µg Source Insect cells Species Human

VEGFR-3 / Flt-4 (Fc Chimera) - DA3536 from Acris Antibodies Category Protein Prices $155.00 Sizes 10 µg Source Insect cells Species Human

VEGFR-3 / Flt-4 (Fc Chimera) - DA3536X from Acris Antibodies Category Protein Prices $350.00 Sizes 50 µg Source Insect cells Species Human

Search more