| Gene Symbol |
NRROS
|
| Entrez Gene |
375387
|
| Alt Symbol |
ELLP3030, GARPL1, LRRC33, UNQ3030
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
negative regulator of reactive oxygen species
|
| Other Description |
leucine-rich repeat-containing protein 33
|
| Swissprots |
Q86YC3
|
| Accessions |
Q86YC3 AA534416 AY358322 AAQ88688 BC034704 BC044233 AAH44233 BQ070837 HY084054 NM_198565 NP_940967
|
| Function |
Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. {ECO:0000250, ECO:0000269|PubMed:23545260}.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:23545260}; Single-pass type I membrane protein {ECO:0000269|PubMed:23545260}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen. {ECO:0000269|PubMed:23545260}.
|