NRROS

Gene Symbol NRROS
Entrez Gene 375387
Alt Symbol ELLP3030, GARPL1, LRRC33, UNQ3030
Species Human
Gene Type protein-coding
Description negative regulator of reactive oxygen species
Other Description leucine-rich repeat-containing protein 33
Swissprots Q86YC3
Accessions Q86YC3 AA534416 AY358322 AAQ88688 BC034704 BC044233 AAH44233 BQ070837 HY084054 NM_198565 NP_940967
Function Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. {ECO:0000250, ECO:0000269|PubMed:23545260}.
Subcellular Location Cell membrane {ECO:0000269|PubMed:23545260}; Single-pass type I membrane protein {ECO:0000269|PubMed:23545260}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen. {ECO:0000269|PubMed:23545260}.

LRRC33 CRISPR/Cas9 KO Plasmid (h) - sc-408493 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 HDR Plasmid (h) - sc-408493-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 Double Nickase Plasmid (h) - sc-408493-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 Double Nickase Plasmid (h2) - sc-408493-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 CRISPR Activation Plasmid (h) - sc-408493-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 CRISPR Activation Plasmid (h2) - sc-408493-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 Lentiviral Activation Particles (h) - sc-408493-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 Lentiviral Activation Particles (h2) - sc-408493-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

LRRC33 siRNA (h) - sc-78022 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRRC33 shRNA Plasmid (h) - sc-78022-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

LRRC33 shRNA (h) Lentiviral Particles - sc-78022-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU009131 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN12726 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND12726 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NRROS siRNA (Human) - CRJ7668 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human LRRC33 (NM_198565.1) - SHH334415 from Creative biogene

Category siRNA
Species Reactivities Human

shRNA set against Human LRRC33(NM_198565.1) - SHH162461 from Creative biogene

Category siRNA
Species Reactivities Human

Human NRROS siRNA - orb278169 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NRROS shRNA Plasmid (Human) - CHJ7668 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

LRRC33 miRNA 3'UTR clone - MiUTR1H-05915 from Creative biogene

Species Reactivities Human
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