NRROS

Gene Symbol	NRROS
Entrez Gene	375387
Alt Symbol	ELLP3030, GARPL1, LRRC33, UNQ3030
Species	Human
Gene Type	protein-coding
Description	negative regulator of reactive oxygen species
Other Description	leucine-rich repeat-containing protein 33
Swissprots	Q86YC3
Accessions	Q86YC3 AA534416 AY358322 AAQ88688 BC034704 BC044233 AAH44233 BQ070837 HY084054 NM_198565 NP_940967
Function	Negative regulator of reactive oxygen species (ROS) that limits ROS production by phagocytes during inflammatory response, thereby playing a role during host defense. Acts via direct interaction with CYBB/NOX2 monomer that impairs interaction between CYBB/NOX2 and CYBA/p22-phox and formation of a stable NOX2 complex (By similarity). May play a critical role in desensitizing TLR signaling through inhibition of Toll-like receptor-mediated NF-kappa-B activation and cytokine production. {ECO:0000250, ECO:0000269|PubMed:23545260}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:23545260}; Single-pass type I membrane protein {ECO:0000269|PubMed:23545260}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}.
Tissue Specificity	Ubiquitous, with high level of expression found in bone marrow, thymus, liver, lung, intestine and spleen. {ECO:0000269|PubMed:23545260}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

NRROS / LRRC33 Antibody Blocking Peptide - LS-E160 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NRROS / LRRC33 Antibody Blocking Peptide - LS-E20241 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

NRROS / LRRC33 Antibody Blocking Peptide - LS-E20240 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

LRRC33-Antibody-C-term-Blocking-peptide - BP10317b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

LRRC33 Blocking Peptide - 33R-5023 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

LRRC33 Blocking Peptide - 33R-3389 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Recombinant Human Leucine-rich repeat-containing protein 33(LRRC33) - CSB-YP801264HU CSB-EP801264HU CSB-BP801264HU CSB-MP801264HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

LRRC33 Protein - NBP1-90478PEP from Novus Biologicals Category Protein Prices $209.00 Sizes 100 µl Species Human

LRRC33 Peptide, Human - M34GP08892H from Creative Peptides Category Peptide Source Synthetic. Species Human

Leucine-rich repeat-containing protein 33 (LRRC33), Recombinant Protein - MBS1366171 from MyBioSource Category Protein Prices $1,055.00, $1,110.00, $1,230.00, $1,425.00, $1,480.00, $1,505.00, $1,560.00, $1,575.00, $1,700.00, $2,230.00, $2,230.00, $2,240.00, $2,570.00, $2,925.00 Sizes 50 µg (E-Coli), 50 µg (Yeast), 50 µg (Baculovirus), 200 µg (E-Coli), 50 µg (Mammalian-Cell), 200 µg (Yeast), 100 µg (Baculovirus), 500 µg (E-Coli), 500 µg (Yeast), 100 µg (Mammalian-Cell), 500 µg (Baculovirus), 1 mg (E-Coli), 1 mg (Yeast), 1 mg (Baculovirus) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Recombinant Human NRROS Protein (19-650 aa), His-Myc-tagged - NRROS-2547H from Creative Biomart Category Protein Source E. coli Species Human

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