Gene Symbol | CRLS1 |
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Entrez Gene | 54675 |
Alt Symbol | C20orf155, CLS, CLS1, GCD10, dJ967N21.6 |
Species | Human |
Gene Type | protein-coding |
Description | cardiolipin synthase 1 |
Other Description | cardiolipin synthase (CMP-forming) |
Swissprots | Q69YQ5 E9PAT4 Q27RP0 D3DW09 Q9UJA2 |
Accessions | EAX10399 EAX10400 EAX10401 EAX10402 Q9UJA2 AF241784 AAG44472 AK310368 AL832419 CAH10649 BC069010 AAH69010 BM763234 BP368984 DQ386730 ABD46888 XM_005260737 XP_005260794 XM_005260738 XP_005260795 XM_006723579 XP_006723642 XM_006723580 XP_006723643 XM_011529262 XP_011527564 XM_011529263 XP_011527565 XM_011529264 XP_011527566 XM_011529265 XP_011527567 NM_001127458 NP_001120930 NM_019095 NP_061968 |
Function | Catalyzes the synthesis of cardiolipin (CL) (diphosphatidylglycerol) by specifically transferring a phosphatidyl group from CDP-diacylglycerol to phosphatidylglycerol (PG). CL is a key phospholipid in mitochondrial membranes and plays important roles in maintaining the functional integrity and dynamics of mitochondria under both optimal and stress conditions. {ECO:0000269|PubMed:16547353, ECO:0000269|PubMed:16678169}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:16547353}; Multi-pass membrane protein {ECO:0000269|PubMed:16547353}. |
Tissue Specificity | Highly expressed in tissues such as heart, skeletal muscle and liver. {ECO:0000269|PubMed:16547353}. |
Top Pathways | Glycerophospholipid metabolism |
Cardiolipin Synthase / CRLS1 Antibody Blocking Peptide - LS-E27745 from LifeSpan Bioscience
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Cardiolipin Synthase / CRLS1 Antibody Blocking Peptide - LS-E17846 from LifeSpan Bioscience
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CRLS1 Peptide - AC21-2556-P from Abcore
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CRLS1 Peptide - 42-880P from ProSci
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cardiolipin synthase 1, Peptide - MBS427587 from MyBioSource
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CRLS1-Blocking-Peptide-C-term - BP5423b from Abgent, a WuXi AppTec company
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CRLS1 Peptide, Human - M34GP03655H from Creative Peptides
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Cardiolipin synthase (CRLS1), Recombinant Protein - MBS7013061 from MyBioSource
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Cardiolipin synthase 1 (cls1), Recombinant Protein - MBS7011764 from MyBioSource
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Cardiolipin synthase 1 (cls1), Recombinant Protein - MBS7011765 from MyBioSource
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Cardiolipin synthase 1 (cls1), Recombinant Protein - MBS7011766 from MyBioSource
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Cardiolipin synthase 1 (cls1), Recombinant Protein - MBS7011767 from MyBioSource
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Cardiolipin synthase 1 (cls1), Recombinant Protein - MBS7011768 from MyBioSource
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Cardiolipin synthase 1 (cls1), Recombinant Protein - MBS7011769 from MyBioSource
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CRLS1 Immunizing peptide - orb59998 from Biorbyt
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