| Gene Symbol |
DEPDC1
|
| Entrez Gene |
55635
|
| Alt Symbol |
DEP.8, DEPDC1-V2, DEPDC1A, SDP35
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
DEP domain containing 1
|
| Other Description |
DEP domain-containing protein 1A|cell cycle control protein SDP35
|
| Swissprots |
Q5TB30 Q9NX21 A8QXE1 Q5TB28 Q05DU3 A8QXE0 Q9NXZ0 Q9H9I3
|
| Accessions |
CAL40387 CAL40388 CAX21632 CAX21633 EAX06471 EAX06472 EAX06473 EAX06474 EAX06475 EAX06476 EAX06477 Q5TB30 AB281187 BAF91373 AB281274 BAF91374 AJ278112 CAB92444 AK000361 BAA91111 AK000490 BAA91201 AK022792 BAB14246 AK225735 AK299324 BAH13001 AL834208 CAH10663 BC003511 AAH03511 BC011743 BC035506 BC041580 BC065304 AAH65304 BU588593 DB147703 NM_001114120 NP_001107592 NM_017779 NP_060249
|
| Function |
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells. {ECO:0000269|PubMed:20587513}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:17452976, ECO:0000269|PubMed:20587513}. Note=Colocalizes with ZNF224 at the nucleus.
|
| Tissue Specificity |
Expressed in testis. Up-regulated in bladder cancer cells (at protein level). {ECO:0000269|PubMed:17452976}.
|
![Western Blot: DEPDC1A Overexpression Lysate (Adult Normal) [NBL1-09833] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for DEPDC1A.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/11012_DEPDC1A%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-09833-img0002.jpg)